Blog

Introduction to Lung Cancer

Lung Cancer, also known as lung carcinoma, is a malignant tumor that originates in the lung tissue. It is typically caused by genetic damage to the DNA of airway cells, often due to smoking or inhalation of harmful chemicals. The damaged airway cells gain the ability to multiply uncontrollably, leading to tumor growth. If left untreated, the tumor can spread throughout the lung, impairing lung function. Eventually, lung tumors can metastasize, spreading to other parts of the body.

The pathological types are mainly divided into two major categories: Small-Cell Lung Cancer (SCLC) and Non-Small-Cell Lung Cancer (NSCLC). Non-Small-Cell Lung Cancer accounts for approximately 80% to 85% of all lung cancer cases, while Small-Cell Lung Cancer accounts for about 10% to 15%. Different types of lung cancer vary in their pathogenesis, treatment, and prognosis.

As one of the malignant tumors with the highest incidence and mortality rates worldwide, the occurrence and development of lung cancer are closely related to the abnormal activation or inhibition of various signaling pathways. An in-depth understanding of the molecular mechanisms of these signaling pathways is of great significance for the early diagnosis, molecular typing, and targeted treatment of lung cancer.

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway plays a crucial role in the occurrence, development, and metastasis of lung cancer. Its abnormal activation can promote the proliferation, invasion of tumor cells, and immune evasion.

TGF-β Signaling Pathway

The TGF-β (Transforming Growth Factor-beta) signaling pathway plays a significant role in the occurrence, progression, and metastasis of lung cancer, and its abnormal activation can promote the proliferation, invasion, and metastasis of cancer cells.

Notch Signaling Pathway

The abnormal activation of this pathway can promote the proliferation and survival of tumor cells.

NF-κB Signaling Pathway

The NF-κB signaling pathway plays a significant role in the occurrence, progression, and immune evasion of lung cancer. Its abnormal activation can promote the proliferation, invasion, and immune evasion of tumor cells.

Voisey  Voisey is a technical support specialist at EnkiLife, proficient in immunology and cell biology. She is     committed to providing customers with professional and efficient technical support. Additionally, she  is involved in research on customers' fields of study and designs highly cost-effective solutions for them.