Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in integrin-mediated signal transduction. It plays an important role in the control of several biological processes, including cell spreading, migration, and survival. Activation of FAK by integrin clustering leads to autophosphorylation at Tyr397, which is a binding site for the Src family kinases PI3K and PLCγ. Recruitment of Src family kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region of FAK.
Schematic diagram of the integrin-FAK-PI4K IIα-GOLPH3-ST axis sialylation regulation mechanism
| Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|
| AMRe05905 | Phospho-FAK (Tyr576) (17X9) Rabbit Monoclonal Antibody | Human, Mouse, Rat | WB, FC |
| APRab04663 | FAK (phospho Tyr925) Rabbit Polyclonal Antibody | Human, Mouse, Rat | WB, IHC-P, IF-P, IF-F, ICC/IF, ELISA |
| AMRe05906 | Phospho-FAK (Y397) (10H3) Rabbit Monoclonal Antibody | Human, Mouse, Rat | WB, ICC/IF |
| AMRe21537 | FAK Rabbit Monoclonal antibody | Human, Mouse, Rat | WB, IHC, IF, IP, ELISA |
| AMRe21414 | Periostin Rabbit Monoclonal antibody | Human | WB, IHC, IF, IP, ELISA |
| APS0635 | HRP-conjugated Polyclonal Goat Anti-Rabbit IgG(H+L) Secondary Antibody | Rabbit | ELISA, WB, Dot blot |
| AMre80004 | GAPDH (12R9) Rabbit Monoclonal Antibody | Human, Mouse, Rat, Rabbit, Dog, Monkey | WB, ELISA |
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References
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- Cobb BS, Schaller MD, Leu TH, Parsons JT. Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK. Mol Cell Biol. 1994 Jan;14(1):147-55.[PMID: 7505391].
- Chen HC, Appeddu PA, Isoda H, Guan JL. Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase. J Biol Chem. 1996 Oct 18;271(42):26329-34.[ PMID: 8824286].
- Zhang X, Chattopadhyay A, Ji QS, et,al. Focal adhesion kinase promotes phospholipase C-gamma1 activity. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9021-6.[PMID: 10430888].
- Calalb MB, Polte TR, Hanks SK. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol. 1995 Feb;15(2):954-63. [PMID: 7529876].
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