HSP27
Heat shock protein (HSP) 27 is one of the small HSPs that are constitutively expressed at different levels in various cell types and tissues. Like other small HSPs, HSP27 is regulated at both the transcriptional and posttranslational levels (1). In response to stress, the HSP27 expression increases several-fold to confer cellular resistance to the adverse environmental change. HSP27 is phosphorylated at Ser15, Ser78, and Ser82 by MAPKAPK-2 as a result of the activation of the p38 MAP kinase pathway (2,3). Phosphorylation of HSP27 causes a change in its tertiary structure, which shifts from large homotypic multimers to dimers and monomers (4). It has been shown that phosphorylation and increased concentration of HSP27 modulates actin polymerization and reorganization (5,6).
Relevant Antibodies
| Catalog# | Product Name | Application | Reactivity |
|---|---|---|---|
| AMRe05920 | Phospho-Hsp27 (S82) (18T2) Rabbit Monoclonal Antibody | WB,IP | Human,Mouse,Rat |
| AMRe12241 | Hsp27 (1A15) Rabbit Monoclonal Antibody | WB,IHC-P,ICC/IF,FC,IP,IF-P | Human,Mouse,Rat |
| APRab04803 | HSP27 (phospho Ser15) Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Monkey |
| APRab04804 | HSP27 (phospho Ser78) Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Rat,Mouse |
| APS0635 | HRP-conjugated Polyclonal Goat Anti-Rabbit IgG(H+L) Secondary Antibody | ELISA,WB,Dotblot | Mouse |
| AMRe80004 | GAPDH (12R9) Rabbit Monoclonal Antibody | WB,ELISA | Human,Mouse,Rat,Rabbit,Dog,Monkey |
Related Products
Super-sensitive ECL chemiluminescent reagent
References
- Stetler, R.A. et al. (2009) Curr Mol Med 9, 863-72.
- Landry, J. et al. (1992) J Biol Chem 267, 794-803.
- Rouse, J. et al. (1994) Cell 78, 1027-37.
- Rogalla, T. et al. (1999) J Biol Chem 274, 18947-56.
- Lavoie, J.N. et al. (1993) J Biol Chem 268, 24210-4.
- Rousseau, S. et al. (1997) Oncogene 15, 2169-77.
- Wang, X. et al. (2023)Journal of Ethnopharmacology 315, 116702.
 | Voisey Voisey is a technical support specialist at EnkiLife, proficient in immunology and cell biology. She is committed to providing customers with professional and efficient technical support. Additionally, she is involved in research on customers' fields of study and designs highly cost-effective solutions for them. |