Vascular Endothelial Growth Factors (VEGFs)
The vascular endothelial growth factor (VEGF) family comprises five secreted homodimeric glycoproteins—VEGF-A, VEGF-B, VEGF-C, VEGF-D and placental growth factor (PlGF)—that selectively bind to VEGFR-1, -2, -3 and the co-receptors neuropilin-1/2, thereby orchestrating angiogenesis, lymphangiogenesis and vascular permeability. VEGF-A is the principal driver of endothelial proliferation, migration and tube formation under hypoxia, growth-factor or oncogenic stimulation. VEGF-B acts predominantly in tumors that do not undergo active neovascularization; VEGF-C and -D preferentially activate VEGFR-3 to promote lymphatic endothelial survival and expansion; VEGF-E is a potent angiogenic factor; and PlGF cooperates with VEGF-A to enhance pathological vessel permeability and inflammatory cell recruitment. Collectively, VEGF signaling is essential for embryonic vasculogenesis, post-natal tissue repair and tumor microenvironment construction, and constitutes the primary target of anti-angiogenic therapies.
Product List
| Target | Catalog# | Product Name | Reactivity | Predicted MW |
|---|---|---|---|---|
PLGF (C-6His) | PHM1319 | Recombinant Mouse PLGF (C-6His) | Mouse | 16.9 kDa |
PLGF-2 (C-6His) | PHH2178 | Recombinant Human PLGF-2 (C-6His) | Human | 18.2 kDa |
| VEGF 164 | PPR1807 | Recombinant Rat VEGF 164 | Rat | 19.2 KDa |
| VEGF 164 | PPM1808 | Recombinant Mouse VEGF 164 | Mouse | 19.27 KDa |
| VEGFR2 (C-Fc) | PHM2137 | Recombinant Mouse VEGFR2 (C-Fc) | Mouse | 110 KDa |
| VEGF-D (C-6His) | PHM1811 | Recombinant Mouse VEGF-D (C-6His) | Mouse | 13.1 KDa |
| VEGFR2 (C-6His) | PHH1996 | Recombinant Human VEGFR2 (C-6His) | Human | 84.3 KDa |
| VEGFB (N-Fc) | PHH1980 | Recombinant Human VEGFB (N-Fc) | Human | 45.7 KDa |
| VEGFR2 (C-Fc) | PHH1813 | Recombinant Human VEGFR2 (C-Fc) | Human | 110.4 KDa |
| VEGFR1 (C-Fc) | PHH1812 | Recombinant Human VEGFR1 (C-Fc) | Human | 109.3 KDa |
| VEGF-D (C-6His) | PHH1810 | Recombinant Human VEGF-D (C-6His) | Human | 13 KDa |
| VEGF-C (C-6His) | PHH1809 | Recombinant Human VEGF-C (C-6His) | Human | 23.27 KDa |
| VEGF165 | PHH1805 | Recombinant Human VEGF165 | Human | 19.1 KDa |
| VEGF 121 (C-6His) | PHH1804 | Recombinant Human VEGF 121 (C-6His) | Human | 15.1 KDa |
| VEGF 121 | PEH1806 | Recombinant Human VEGF 121 | Human | 14.2 KDa |
Validation Data
Recombinant Mouse PLGF (C-6His) (Catalog: PHM1319） Recombinant Human VEGFR2 (C-6His) (Catalog: PHH1996)
Related Products
Super-sensitive ECL chemiluminescent reagent
References
1. The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease. Ferrara N, et al. Trends Cell Biol. 2003. [PMID: 15693956]
2. The biology of VEGF and its receptors. Ferrara N, et al. Nat Med. 2003. [PMID: 12778165]
3. VEGF receptor signalling—in control of vascular function. Olsson A-K, et al. Nat Rev Mol Cell Biol. 2006. [PMID: 16633338]