Hypoxia Signaling Pathway

References

• HIF1 and oxygen sensing in the brain. Sharp FR, et al. Nat Rev Neurosci. 2004. [PMID: 15152194]
• Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Wang GL, et al. Proc Natl Acad Sci U S A. 1995 . [PMID: 7539918]
• Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Jaakkola P, et al. Science. 2001. [PMID: 11292861]
• The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Maxwell PH, et al. Nature. 1999. [PMID: 10353251]
• Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. Fukuda R, et al. J Biol Chem. 2002. [PMID: 12149254]
• Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Jiang BH, et al. Cell Growth Differ. 2001. [PMID: 11457733]
• HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Laughner E, et al. Mol Cell Biol. 2001. [PMID: 11359907]