PO4F2_MOUSE Q63934
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UniProt:Q63934
Recommended name：POU domain, class 4, transcription factor 2
EC number：
Alternative names：(Brain-specific homeobox/POU domain protein 3B) (Brain-3B) (Brn-3B) (Brn-3.2)
Cleaved into：
GeneID：18997
Gene names (primary )：Pou4f2
Gene names (synonym )：Brn-3.2 Brn3b
Gene names (ORF )：
Length：411
Mass：43173
Sequence：MMMMSLNSKQAFSMPHAGSLHVEPKYSALHSASPGSSAPAAPSASSPSSSSNAGGGGGGGGGGGGGGRSSSSSSSGSGGSGGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGTVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI
Tissue specificity：Expressed in retinal ganglion cells (RGCs) (PubMed:21875655, PubMed:23805044). Expressed in mature osteoclasts (PubMed:17668438). Expressed in cells of layers of the superior colliculus and the adjacent periaqueductal gray (at protein level) (PubMed:7691107). Expressed in the brain, peripheral sensory nervous system and retina (PubMed:7904822). Expressed in the optical, intermediate, and deep gray areas of the superior colliculus, the dorsal column of the mesencephalic and pontine central gray, and the lateral interpeduncular nucleus of the brain (PubMed:7904822). Expressed predominantly in postmitotic, terminally differentiated neurons (PubMed:7904822). Expressed in ganglion cell layer (GCL) of the retina (PubMed:7691107, PubMed:23805044). {ECO:0000269|PubMed:17668438, ECO:0000269|PubMed:21875655, ECO:0000269|PubMed:23805044, ECO:0000269|PubMed:7691107, ECO:0000269|PubMed:7904822}.
Induction：Up-regulated by the osteoclast differentiation factor TNFSF11 (PubMed:17668438). Down-regulated upon neuronal differentiation (PubMed:8995448). Down-regulated in presence of retinoic acid (PubMed:7904822). Down-regulated by dibutyryl cyclic AMP (PubMed:8065921). {ECO:0000269|PubMed:17668438, ECO:0000269|PubMed:7904822, ECO:0000269|PubMed:8065921, ECO:0000269|PubMed:8995448}.
Developmental stage：Weakly expressed in the dorsal root ganglion neurons at 10.5 dpc, the expression increases at least until 15.5 dpc (PubMed:22326227). Expressed in the developing ganglion cell layer of the retina at 12.5, 13.5 and 16.5 dpc (PubMed:8632990). Expressed in the outer margin of the retina at 15.5 dpc (PubMed:10414983). Expressed in embryonic heart from 13.5 dpc until birth (at protein level) (PubMed:18368538). Expressed in the developing spinal cord from 13 dpc until postnatal day 1 (PubMed:8290353, PubMed:8537352). Expressed in retinal ganglion cells (RGC) at 13.5 dpc, peaks at 15.5 dpc, declining later in development (PubMed:8637595). {ECO:0000269|PubMed:10414983, ECO:0000269|PubMed:18368538, ECO:0000269|PubMed:22326227, ECO:0000269|PubMed:8290353, ECO:0000269|PubMed:8537352, ECO:0000269|PubMed:8632990, ECO:0000269|PubMed:8637595}.
Protein families：POU transcription factor family, Class-4 subfamily