MOGT2_MOUSE Q80W94
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UniProt:Q80W94
Recommended name：2-acylglycerol O-acyltransferase 2
EC number：EC 2.3.1.22
Alternative names：(Acyl-CoA:monoacylglycerol acyltransferase 2) (MGAT2) (Diacylglycerol acyltransferase 2-like protein 5) (Monoacylglycerol O-acyltransferase 1-like) (Monoacylglycerol O-acyltransferase 2)
Cleaved into：
GeneID：233549
Gene names (primary )：Mogat2
Gene names (synonym )：Dgat2l5 Mgat1l
Gene names (ORF )：
Length：334
Mass：38591
Sequence：MVEFAPLLVPWERRLQTFAVLQWVFSFLALAQLCIVIFVGLLFTRFWLFSVLYATWWYLDWDKPRQGGRPIQFFRRLAIWKYMKDYFPVSLVKTAELDPSRNYIAGFHPHGVLAAGAFLNLCTESTGFTSLFPGIRSYLMMLTVWFRAPFFRDYIMSGGLVSSEKVSADHILSRKGGGNLLAIIVGGAQEALDARPGAYRLLLKNRKGFIRLALMHGAALVPIFSFGENNLFNQVENTPGTWLRWIQNRLQKIMGISLPLFHGRGVFQYSFGLMPFRQPITTIVGKPIEVQMTPQPSREEVDRLHQRYIKELCKLFEEHKLKFNVPEDQHLEFC
Tissue specificity：Mainly expressed in small intestine. Detected in the small intestine in a proximal-to-distal gradient that correlated with fat absorption pattern. Present not only in the villi, but also in the crypt regions of the small intestine, which suggests that expression occurs prior to the maturation of enterocytes. Not detectable in other sections of the digestive tract, including stomach, cecum, colon and rectum, or other tissues such as kidney, liver and adipocytes (at protein level). Also detected in kidney, adipose and stomach. Expressed at very low level in liver, skeletal muscle and spleen. Not expressed in brain, heart, lung, skin, testis and thymus. {ECO:0000269|PubMed:12576479, ECO:0000269|PubMed:12621063, ECO:0000269|PubMed:14966132}.
Induction：Up-regulated in mice fed a high fat diet, implicating a role in diet-induced obesity (at protein level). {ECO:0000269|PubMed:14966132}.
Developmental stage：
Protein families：Diacylglycerol acyltransferase family