ASCL1_MOUSE Q02067
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UniProt:Q02067
Recommended name：Achaete-scute homolog 1
EC number：
Alternative names：(ASH-1) (mASH-1) (mASH1)
Cleaved into：
GeneID：17172
Gene names (primary )：Ascl1
Gene names (synonym )：Ash1 Mash-1 Mash1
Gene names (ORF )：
Length：231
Mass：24741
Sequence：MESSGKMESGAGQQPQPPQPFLPPAACFFATAAAAAAAAAAAAQSAQQQQPQAPPQQAPQLSPVADSQPSGGGHKSAAKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF
Tissue specificity：Developing CNS and PNS at embryonic and postnatal stages. Expressed in the epithelium of glandular stomach (PubMed:18173746). {ECO:0000269|PubMed:16020526, ECO:0000269|PubMed:18173746, ECO:0000269|PubMed:8217843, ECO:0000269|PubMed:8424959}.
Induction：
Developmental stage：Between 8.5 dpc and 10.5 dpc it is found in the neuroepithelium of the midbrain and ventral forebrain, as well as in the spinal cord. Between 10.5 dpc and 12.5 dpc its expression pattern changes from a restricted to a widespread zone, it is then found at variable levels in the ventricular zone in all regions of the brain, where is expressed in a subset of p2 progenitors that can give rise to either V2a or V2b interneuron subtypes. From 12.5 dpc to postnatal stages it is also expressed in cells outside of the ventricular zone through the brain, and in addition it is also expressed during development of the olfactory epithelium and neural retina. At 12.5 dpc, it is highly expressed by differentiating enteric neurons in the mesenchyme of the stomach. At 14.5 and 16.5 dpc, it is also expressed in the epithelium of the glandular stomach (PubMed:18173746). {ECO:0000269|PubMed:16020526, ECO:0000269|PubMed:18173746, ECO:0000269|PubMed:8217843, ECO:0000269|PubMed:8424959}.
Protein families：