RTEL1_MOUSE Q0VGM9
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UniProt:Q0VGM9
Recommended name：Regulator of telomere elongation helicase 1
EC number：EC 3.6.4.12
Alternative names：
Cleaved into：
GeneID：269400
Gene names (primary )：Rtel1
Gene names (synonym )：Kiaa1088 Rtel
Gene names (ORF )：
Length：1203
Mass：133767
Sequence：MPRVVLNGVTVDFPFQPYPCQQEYMTKVLECLQKKVNGILESPTGTGKTLCLLCSTLAWQQHLRDAVSSLKIAERVQGELFASRTLSSWGSAAAASGDSIECYTDIPKIIYASRTHSQLTQVIRELRNTAYRPKVCVLGSREQLCIHPEVKKQESNHMQISLCRKKVASRSCHFYNNVEAKFLEQDLATPILDIEDLVKNGSKQKMCPYYLSRNMKQQADIIFMPYNYLLDAKSRKAHSIDLKGTVVIFDEAHNVEKICEESASFDLTPRDVASGLEIINQVLEEQARVTQQGELQQEFIVDTSSSGLNMELEDIAKLKMILLRLEEAIDAVQLPGDDRGVTKPGSYIFELFAEAQITFQTKGCILESLDQIIQHLAGRTGVFTNTAGLQKLMDIIQIVFSVDPPEGSPGSLVGLGISHSYKVHIHPETSHRRAAKRSDAWSTTASRKQGKVLSYWCFSPSQSMRELVCQGVRTLILTSGTLAPLSSFALEMQIPFPVCLENPHIIDKNQLWVGIVPRGPDGVQLSSAYDKRFSEECLSSLGKALSNIARVVPHGLLVFFPSYPVMEKSLEFWQVQGLARKVEALKPLFVEPRNKGSFSEVIDAYYQQVASPASNGATFLAVCRGKASEGLDFSDMNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMRGRSGVGGQCLSGQEWYQQQASRAVNQAIGRVIRHRHDYGAIFLCDHRFAYADARAQLPSWVRPYLKVYDNFGHVIRDVAQFFRVAQKTMPLPVPQAVTSSVSEGEIALKDATLSSYSLSTRKAMSLDVHVPSLRQKPIGLPAAGDSESSLCGEYEQQTFSAQQRPMGLLAALEYNEQKAGASEEQALGSSTPSLRCEKRLSTEQKGGRKKVRLVNHPEEPMAGTQAGRAKMFMVAVKQALSQANFDTFTQALQHYKSSDDFEALVASLTCLFAEDPKKHTLLKGFYQFVRPHHKQQFEDICFQLTGQRCGYQPGKRELESKLTLSEGVDRQLDPGQHLNQGQPHLSAHPTSKGHTSHCTKVGCAVEKPGQPAVSDYLSDVHKALGSASCNQLTAALRAYKQDDDLDKVVAVVAALTTAKPEHLPLLQRFGMFVRRHHKPQFLQTCADLMGLPTTGKDLELEGPRDESPTVPPELTHEDLKPGPSMSKKPEKTQSKISSFFRQRPDESVRSDDTTPKPMQLPPRLPHELMKPHRSKQ
Tissue specificity：Widely expressed. Expressed in spleen, thymus, Peyer patches, kidney, and intestine. Not expressed in brain, heart, lung, skeletal muscles, skin and white fat. In the adult gonad, it is highly expressed in the testis, mainly in the spermatogonia and meiotic spermatocytes. {ECO:0000269|PubMed:15210109}.
Induction：
Developmental stage：Widely expressed in 8.5 dpc and 9.5 dpc embryos with a more restricted expression pattern at 13.5 dpc-15.5 dpc. In general, expression in embryos coincides with areas of actively proliferating cells.
Protein families：Helicase family, RAD3/XPD subfamily