SIX1_MOUSE Q62231
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UniProt:Q62231
Recommended name：Homeobox protein SIX1
EC number：
Alternative names：(Sine oculis homeobox homolog 1)
Cleaved into：
GeneID：20471
Gene names (primary )：Six1
Gene names (synonym )：
Gene names (ORF )：
Length：284
Mass：32210
Sequence：MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNSSSNKQNQLSPLEGGKPLMSSSEEEFSPPQSPDQNSVLLLQSNMGHARSSNYSLPGLTASQPSHGLQAHQHQLQDSLLGPLTSSLVDLGS
Tissue specificity：Expressed in phalangeal tendons and in skeletal muscle and in head and body mesenchyme.
Induction：
Developmental stage：First expressed at 8.2-8.5 dpc of embryo development in the anterior head mesoderm and developing pharyngeal pouches. Expression in the developing limb begins at 11 dpc and is more pronounced dorsally. It progresses into the developing phalanges at 13.5 dpc. In the developing inner ear detected in the otic placode and the surrounding surface ectoderm at 8.5 dpc. Expression became prominent at the invaginating otic pit and the nascent otic vesicle at 9.5 dpc. At 10.5 dpc, expression was limited to the ventral half of the otic vesicle. Subsequently, the expression became gradually restricted to the cochlear region at 11.5 dpc and 12.5 dpc. At later stages detected exclusively in the cochlea at 14.5 dpc, and the expression in the cochlear duct persisted in the neonate. In the developing kidney, is expressed in the uninduced metanephric mesenchyme at 10.5 dpc and in the induced mesenchyme around the ureteric bud at 11.5 dpc. At 17.5 dpc to P0, expression becomes restricted to a subpopulation of collecting tubule epithelial cells. {ECO:0000269|PubMed:12783782, ECO:0000269|PubMed:14695375}.
Protein families：SIX/Sine oculis homeobox family