OLIG3_MOUSE Q6PFG8
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UniProt:Q6PFG8
Recommended name：Oligodendrocyte transcription factor 3
EC number：
Alternative names：(Oligo3) (Class B basic helix-loop-helix protein 7) (bHLHb7) (Oligodendrocyte-specific bHLH transcription factor 3)
Cleaved into：
GeneID：94222
Gene names (primary )：Olig3
Gene names (synonym )：Bhlhb7
Gene names (ORF )：
Length：273
Mass：29507
Sequence：MNSDSSSVSSRASSPDMDEMYLRDHHHRHHHHHQESRLNSVSSTQGDMVQKMPGESLSRAGAKAAGESSKYKIKKQLSEQDLQQLRLKINGRERKRMHDLNLAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTSSLEEMKRLVGEIYGGHHSAFHCGTVGHSAGHPAHAANAVHPVHPILGGALSSGNASSPLSATSLPTIGTIRPPHSLLKAPSTPPALQLGSGFQHWAGLPCPCTICQMPPPPHLSALSTANMARLSAESKDLLK
Tissue specificity：Weakly expressed, mainly in non-neural tissues. {ECO:0000269|PubMed:15489334}.
Induction：
Developmental stage：Restricted to the CNS. At 9.25 and 10.5 dpc, specifically expressed in the dorsal neural tube from the midbrain/hindbrain boundary to the spinal cord. At 10.5 dpc, expressed continuously from the upper rhombic lip to the tail. From 10.5 to 12.5 dpc, located in the most dorsal aspect of the spinal cord, excluding the roof plate, mainly in proliferating progenitor cells; quickly down-regulated in postmitotic neurons. At 11.5 dpc, 3 ventral expression clusters, corresponding to p3, p2 and p0 domains, transiently appear on the lateral margin of the subventricular zone, in addition to dorsal expression. At 14.5 dpc, weakly expressed in cells scattered in the mantle zone. Expression declines after 15.5 dpc. In the 11.5 dpc forebrain, expressed in the ventricular zone of the dorsal thalamus. In the 11.5 to 14.5 dpc hindbrain, dorsally expressed in the upper and lower rhombic lip, in the cerebellar neuroepithelium. {ECO:0000269|PubMed:11960707, ECO:0000269|PubMed:15769945}.
Protein families：