TOMT_MOUSE A1Y9I9
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UniProt:A1Y9I9
Recommended name：Transmembrane O-methyltransferase homolog
EC number：EC 2.1.1.6
Alternative names：(mTOMT) (Catechol O-methyltransferase 2) (Protein LRTOMT2)
Cleaved into：
GeneID：791260
Gene names (primary )：Tomt
Gene names (synonym )：Comt2
Gene names (ORF )：
Length：258
Mass：28846
Sequence：MSPAIALAFLPLVVTLLVRYRHHFRLLVRTVLLRGFRDCLSGLRIEERAFSYVLTHALPGDPGHILTTLDHWSSCCEYLSHMGPVKGQILMRLVEEKAPACVLELGTYCGYSTLLIARALPPGSRLLTVERDSRTAAVAEKVIRLAGFDEQMVELIAGSSEEVIPRLRAQHQLNRADLVLLAHRPRYYLRDLQLLEAHALLPHGATVLADHVLFPGAPRFLQYTKSCGRYRCRLHHTSLPDFPAIKDGIAQLTYTGPG
Tissue specificity：Widely expressed with high levels in outer and inner hair cells of the cochlea and vestibule. {ECO:0000269|PubMed:18794526, ECO:0000269|PubMed:18953341}.
Induction：
Developmental stage：Not detected in the embryo at 12.5 dpc. At 14.5 dpc, expressed in the developing inner ear. At 16.5 dpc, expressed in the utricle and saccule. At 18.5 dpc, expressed specifically in the region of the sensory cells of the cochlea, utricle, saccule and crista ampullaris. {ECO:0000269|PubMed:18953341}.
Protein families：Class I-like SAM-binding methyltransferase superfamily, Cation-dependent O-methyltransferase family