IKKB_MOUSE O88351
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UniProt:O88351
Recommended name：Inhibitor of nuclear factor kappa-B kinase subunit beta
EC number：EC 2.7.11.10
Alternative names：(I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Cleaved into：
GeneID：16150
Gene names (primary )：Ikbkb
Gene names (synonym )：Ikkb
Gene names (ORF )：
Length：757
Mass：86690
Sequence：MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQELSPKNRNRWCLEIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREGAVLTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCFRALDDILNLKLVHVLNMVTGTVHTYPVTEDESLQSLKTRIQENTGILETDQELLQKAGLVLLPDKPATQCISDSKTNEGLTLDMDLVFLLDNSKINYETQITPRPPPESVSCILQEPKRNLSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMSLLRNNSCLSKMKNAMASTAQQLKAKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRKLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDERTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNVSRLSHPGQLMSQPSSACDSLPESDKKSEELVAEAHALCSRLESALQDTVKEQDRSFTTLDWSWLQMEDEERCSLEQACD
Tissue specificity：Detected in heart (at protein level) (PubMed:23090968). Expressed in liver, kidney and spleen. {ECO:0000269|PubMed:23090968}.
Induction：
Developmental stage：While it is expressed ubiquitously throughout the mouse embryo, at 9.5 dpc its expression begins to be localized to the brain, neural ganglia, neural tube, and in liver at 12.5 dpc. At 15.5 dpc, the expression is further restricted to specific tissues of the embryo. {ECO:0000269|PubMed:10523828}.
Protein families：Protein kinase superfamily, Ser/Thr protein kinase family, I-kappa-B kinase subfamily