Glycogen synthase kinase-3 (GSK-3)
Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.
Product List
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
GSK3α | GSK3α Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA |
Related Products
Super-sensitive ECL chemiluminescent reagent
References
- GSK3 and its interactions with the PI3K/AKT/mTOR signalling network. Hermida MA, et al. Adv Biol Regul. 2017. [PMID: 28712664]
- Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases. Beurel E, et al. Pharmacol Ther. 2015. [PMID: 25435019]
- GSK3: A potential target and pending issues for treatment of Alzheimer's disease. Zhao J, et al. CNS Neurosci Ther. 2024. [PMID: 38946682]
- GSK3: A Kinase Balancing Promotion and Resolution of Inflammation. Hoffmeister L, et al. Cells. 2020. [PMID: 32231133]
- GSK3 is a Central Player in Retinal Degenerative Diseases but a Challenging Therapeutic Target. Hottin C, et al. Cells. 2022. [PMID: 36139472]
- Targeting GSK3 and Associated Signaling Pathways Involved in Cancer. Duda P, et al. Cells. 2020. [PMID: 32365809]
