PSB8_HUMAN P28062
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UniProt:P28062
Recommended name：Proteasome subunit beta type-8
EC number：EC:3.4.25.1
Alternative names：(Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i) (Really interesting new gene 10 protein)
Cleaved into：
GeneID：5696
Gene names (primary )：PSMB8
Gene names (synonym )：LMP7 PSMB5i RING10 Y2
Gene names (ORF )：
Length：276
Mass：30354
Sequence：MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
Tissue specificity：
Induction：Up-regulated by IFNG/IFN-gamma and IRF1 (at protein level). Up-regulated by TNF (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel disease (CD). Down-regulated by the selective inhibitor PR-957. Down-regulated in mature dendritic cells by HSV-1 infection. Up-regulated by heat shock treatment. {ECO:0000269|PubMed:11493458, ECO:0000269|PubMed:15501285, ECO:0000269|PubMed:15907481, ECO:0000269|PubMed:17142736, ECO:0000269|PubMed:17262812, ECO:0000269|PubMed:19443843, ECO:0000269|PubMed:19525961, ECO:0000269|PubMed:19619915, ECO:0000269|PubMed:8663318}.
Developmental stage：Highly expressed in immature dendritic cells (at protein level). {ECO:0000269|PubMed:11717192}.
Protein families：Peptidase T1B family