HELLS_MOUSE Q60848
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UniProt:Q60848
Recommended name：Lymphocyte-specific helicase
EC number：EC 3.6.4.-
Alternative names：(Proliferation-associated SNF2-like protein)
Cleaved into：
GeneID：15201
Gene names (primary )：Hells
Gene names (synonym )：Lsh Pasg
Gene names (ORF )：
Length：821
Mass：95126
Sequence：MAEQTEPAVITPAMLEEEEQLEAAGLEKERKMLEEAQKSWDRESTEIRYRRLQHLLEKSNIYSKFLLTKMEQQQLEEQKKKEKLEKKKRSLKLTEGKSLVDGNGEKPVMKKKRGREDESYNISEVMSKEEILSVAKKHKDNEDESSSTTSLCVEDIQKNKDSNSMIKDRLSQTVRQNSKFFFDPVRKCNGQPVPFQQPKHFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIALMIQRGVPGPFLVCGPLSTLPNWMAEFKRFTPEIPTLLYHGTREDRRKLVKNIHKRQGTLQIHPVVVTSFEIAMRDQNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLRRLKSDVALEVPPKREVVVYAPLCNKQEIFYTAIVNRTIANMFGSCEKETVELSPTGRPKRRSRKSINYSELDQFPSELEKLISQIQPEVNRERTVVEGNIPIESEVNLKLRNIMMLLRKCCNHPYMIEYPIDPVTQEFKIDEELVTNSGKFLILDRMLPELKKRGHKVLVFSQMTSMLDILMDYCHLRNFIFSRLDGSMSYSEREKNIYSFNTDPDVFLFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQSGLSQSKNFLDAKELMELLKSRDYEREVKGSREKVISDEDLELLLDRSDLIDQMKASRPIKGKTGIFKILENSEDSSAECLF
Tissue specificity：Highly expressed in thymus, bone marrow, and testis. Not detected in heart, brain, liver, kidney, skeletal muscle, spleen, peripheral blood lymphocytes, small intestine, colon, prostate or ovary. {ECO:0000269|PubMed:11325543, ECO:0000269|PubMed:11357197, ECO:0000269|PubMed:9878251}.
Induction：By concanavalin or lipopolysaccharide in unactivated splenocytes. {ECO:0000269|PubMed:10781083, ECO:0000269|PubMed:8647447}.
Developmental stage：Differentially expressed during embryonic development, with highest expression in developing face, limbs, skeletal muscle, heart, and tail. Highly expressed in fetal thymocytes from day 14 to 16 of gestation, and expressed at much lower levels in adult thymus. {ECO:0000269|PubMed:10781083, ECO:0000269|PubMed:11357197, ECO:0000269|PubMed:8647447}.
Protein families：SNF2/RAD54 helicase family