IKKE_MOUSE Q9R0T8
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UniProt:Q9R0T8
Recommended name：Inhibitor of nuclear factor kappa-B kinase subunit epsilon
EC number：EC 2.7.11.10
Alternative names：(I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (Inducible I kappa-B kinase) (IKK-i)
Cleaved into：
GeneID：56489
Gene names (primary )：Ikbke
Gene names (synonym )：Ikke Ikki
Gene names (ORF )：
Length：717
Mass：80953
Sequence：MQSTTNYLWHTDDLLGQGATASVYKARNKKSGEVVAVKVFNSASYRRPPEVQVREFEVLRRLNHQNIVKLFAVEETGGSRQKVLIMEYCSSGSLLSVLEDPENTFGLSEEEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLSDFGAARKLDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAISGTQKQENGPLEWSYSLPITCRLSMGLQNQLVPILANILEVEEDKCWGFDQFFAETSDILQRTVIHVFSLPQAVLHHVYIHAHNTIAIFLEAVYEQTNVTPKHQEYLFEGHPCVLEPSLSAQHIAHTAASSPLTLFSMSSDTPKGLAFRDPALDVPKFVPKVDLQADYSTAKGVLGAGYQALWLARVLLDGQALMLRGLHWVLEVLQDTCQQTLEVTRTALLYLSSSLGTERFSSGAGMPDVQERKEATELRTRLQTLSEILSKCSHNVTETQRSLSCLGEELLKNRDQIHEDNKSIQKIQCCLDKMHFIYKQFKKSRMRPGLSYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQTYQVSLVTHGKRMRQVQRAQNHLHLIGHSVATCNSEARGAQESLNKIFDQLLLDRASEQGAEVSPQPMAPHPGPDPKDLVFHMQELCNDMKLLAFDLQDNNRLIERLHRVPSAPDV
Tissue specificity：Expressed in bone marrow-derived macrophages and at low levels in liver and white adipose tissue (at protein level). Detected in muscle and lung. {ECO:0000269|PubMed:17332413, ECO:0000269|PubMed:19737522, ECO:0000269|PubMed:23396211}.
Induction：Induced by lipopolysaccharide (LPS) and TNFA. Under high-fat diet, highly induced (via NF-kappa-B) in adipocytes and M1-polarized adipose tissue macrophages. {ECO:0000269|PubMed:19737522, ECO:0000269|PubMed:23396211}.
Developmental stage：
Protein families：Protein kinase superfamily, Ser/Thr protein kinase family, I-kappa-B kinase subfamily