TREM2_MOUSE Q99NH8
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UniProt:Q99NH8
Recommended name：Triggering receptor expressed on myeloid cells 2
EC number：
Alternative names：(TREM-2) (Triggering receptor expressed on monocytes 2)
Cleaved into：
GeneID：83433
Gene names (primary )：Trem2
Gene names (synonym )：Trem2a Trem2b Trem2c
Gene names (ORF )：
Length：227
Mass：24527
Sequence：MGPLHQFLLLLITALSQALNTTVLQGMAGQSLRVSCTYDALKHWGRRKAWCRQLGEEGPCQRVVSTHGVWLLAFLKKRNGSTVIADDTLAGTVTITLKNLQAGDAGLYQCQSLRGREAEVLQKVLVEVLEDPLDDQDAGDLWVPEESSSFEGAQVEHSTSRNQETSFPPTSILLLLACVLLSKFLAASILWAVARGRQKPGTPVVRGLDCGQDAGHQLQILTGPGGT
Tissue specificity：Expressed in the brain, specifically in microglia (at protein level) (PubMed:15728241, PubMed:28802038, PubMed:28855301, PubMed:28077724, PubMed:28592261, PubMed:29794134, PubMed:29752066, PubMed:27477018, PubMed:28559417). Expressed in macrophages (at protein level) (PubMed:11241283, PubMed:28802038, PubMed:28559417). Expressed at higher levels in the CNS, heart and lung than in lymph nodes or in other non-lymphoid tissues such as kidney, liver and testis (PubMed:12472885). In the CNS not all microglia express TREM2 (PubMed:12472885). Brain regions with an incomplete blood-brain barrier had the lowest percentages of TREM2 expressing microglia, whereas the lateral entorhinal and cingulate cortex had the highest percentages (PubMed:12472885). {ECO:0000269|PubMed:11241283, ECO:0000269|PubMed:12472885, ECO:0000269|PubMed:15728241, ECO:0000269|PubMed:27477018, ECO:0000269|PubMed:28077724, ECO:0000269|PubMed:28559417, ECO:0000269|PubMed:28592261, ECO:0000269|PubMed:28802038, ECO:0000269|PubMed:28855301, ECO:0000269|PubMed:29752066, ECO:0000269|PubMed:29794134}.
Induction：Expression is increased during oxygen-glucose deprivation, reaching the highest expression level 12 hours after reoxygenation. Expression is also increased by ischemia, where maximum expression is reached 7 days after ischemic conditions. {ECO:0000269|PubMed:28592261}.
Developmental stage：
Protein families：