PCSK5_MOUSE Q04592
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UniProt:Q04592
Recommended name：Proprotein convertase subtilisin/kexin type 5
EC number：EC 3.4.21.-
Alternative names：(Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6) (Subtilisin/kexin-like protease PC5)
Cleaved into：
GeneID：18552
Gene names (primary )：Pcsk5
Gene names (synonym )：
Gene names (ORF )：
Length：1877
Mass：209257
Sequence：MDWDWGNRCSRPGRRDLLCVLALLAGCLLPVCRTRVYTNHWAVKIAGGFAEADRIASKYGFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDLSHAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSYNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGAEDYAGPCDPECSEVGCDGPGPDHCSDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGNQCLSCKYGYFLNEETSSCVTQCPDGSYEDIKKNVCGKCSENCKACIGFHNCTECKGGLSLQGSRCSVTCEDGQFFNGHDCQPCHRFCATCSGAGADGCINCTEGYVMEEGRCVQSCSVSYYLDHSSEGGYKSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGTCQMGAICKDGEYIDDQGHCQTCEASCAKCWGPTQEDCISCPVTRVLDDGRCVMNCPSWKFEFKKQCHPCHYTCQGCQGSGPSNCTSCRADKHGQERFLYHGECLENCPVGHYPAKGHACLPCPDNCELCYNPHVCSRCMSGYVIIPPNHTCQKLECRQGEFQDSEYEECMPCEEGCLGCTEDDPGACTSCATGYYMFERHCYKACPEKTFGVKWECRACGTNCGSCDQHECYWCEEGFFLSGGSCVQDCGPGFHGDQELGECKPCHRACENCTGSGYNQCSSCQEGLQLWHGTCLWSTWPQVEGKDWNEAVPTEKPSLVRSLLQDRRKWKVQIKRDATSQNQPCHSSCKTCNGSLCASCPTGMYLWLQACVPSCPQGTWPSVTSGSCEKCSEDCVSCSGADLCQQCLSQPDNTLLLHEGRCYHSCPEGFYAKDGVCEHCSSPCKTCEGNATSCNSCEGDFVLDHGVCWKTCPEKHVAVEGVCKHCPERCQDCIHEKTCKECMPDFFLYNDMCHRSCPKSFYPDMRQCVPCHKNCLECNGPKEDDCKVCADTSKALHNGLCLDECPEGTYKEEENDECRDCPESCLICSSAWTCLACREGFTVVHDVCTAPKECAAVEYWDEGSHRCQPCHKKCSRCSGPSEDQCYTCPRETFLLNTTCVKECPEGYHTDKDSQQCVLCHSSCRTCEGPHSMQCLSCRPGWFQLGKECLLQCRDGYYGESTSGRCEKCDKSCKSCRGPRPTDCQSCDTFFFLLRSKGQCHRACPEHYYADQHAQTCERCHPTCDKCSGKEAWSCLSCVWSYHLLKGICIPECIVGEYREGKGENFNCKKCHESCMECKGPGSKNCTGCSAGLLLDMDDNRCLHCCNASHSRRSQDCCDCQSSTDECILPAREAEFYEHTKTALLVTSGAMLLLLLGAAAVVWRKSRSRPVAKGRYEKLAEPTVSYSSYRSSYLDEDQVIEYRDRDYDEDDEDDIVYMGQDGTVYRKFKYGLLDETEDDELEYDDESYSYQ
Tissue specificity：PC5A is expressed in most tissues but is most abundant in the intestine and adrenals. PC5B is expressed in the intestine, adrenals and lung but not in the brain.
Induction：
Developmental stage：Weakly expressed throughout the embryo, except in the developing nervous system, the ribs and the liver, but markedly up-regulated at discrete sites during development. At 6.5 dpc, prominent expression observed in differentiated decidua. At 7.5 dpc, intense expression in extraembryonic endoderm, amnion and nascent mesoderm. At 8.5 dpc, abundant expression in somites and yolk sac followed by a confinement to dermamyotome compartment. Between 9.5 dpc and 11.5 dpc, abundant expression in AER (thickened ectodermal cells of limb buds). At 12.5 dpc, expression in the limbs is confined to the condensing mesenchyme surrounding the cartilage. At this stage, strong expression also detected in vertebral and facial cartilage primordia and in the muscle of the tongue. At 16.5 dpc, abundant expression in epithelial cells of the intestinal villi. Isoform A is most abundant at all stages but significant levels of isoform B occur at 12.5 dpc. {ECO:0000269|PubMed:8698813, ECO:0000269|PubMed:9291583}.
Protein families：Peptidase S8 family