PO2F2_MOUSE Q00196
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UniProt:Q00196
Recommended name：POU domain, class 2, transcription factor 2
EC number：
Alternative names：(Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2)
Cleaved into：
GeneID：18987
Gene names (primary )：Pou2f2
Gene names (synonym )：Oct2 Otf2
Gene names (ORF )：
Length：463
Mass：49439
Sequence：MVHSSMGAPEIRMSKPLEAEKQSLDSPSEHTDTERNGPDINHQNPQNKASPFSVSPTGPSTKIKAEDPSGDSAPAAPPPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPTSYSPHLVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGGGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSAGPGLWWNPAPYQP
Tissue specificity：Highest in B cells, but also present in brain (neuronal and glial cells), intestine, kidney, and testes. {ECO:0000269|PubMed:1281152, ECO:0000269|PubMed:17285328, ECO:0000269|PubMed:23045607}.; [Isoform OCT2.1]: Expressed at higher levels in B-cells than in neuronal cells. {ECO:0000269|PubMed:1281152}.; [Isoform OCT2.2]: Expressed in neuronal cell lines and brain, but not dorsal root ganglia. {ECO:0000269|PubMed:1281152}.; [Isoform OCT2.3]: Expressed at lower levels in neuronal cells than in B cells. {ECO:0000269|PubMed:1281152}.; [Isoform OCT2.4]: Expressed in neuronal cell lines, and at lower levels in neuroblastoma and dorsal root ganglia. {ECO:0000269|PubMed:1281152}.; [Isoform OCT2.5]: Widely expressed in the developing nervous system but expression is confined to very specific regions in the adult brain, it is expressed at a lower level in B cells. {ECO:0000269|PubMed:1281152}.; [Isoform OCT2.6]: Either absent in, or expressed at very low levels in neuronal cells and brain. {ECO:0000269|PubMed:1281152}.; [Isoform OCT2.7]: Expressed in all tissues tested: mammary gland, liver, spleen, lung, kidney intestine, uterus and ovary of a virgin mouse. Levels of isoform OCT2.7 are highest in spleen and lung. In mammary gland, expression is localized to the alveolus epithelial cells. {ECO:0000269|PubMed:17285328}.
Induction：In B cells, expression is highly increased upon activation by LPS or CpG. {ECO:0000269|PubMed:23045607}.
Developmental stage：Widely but not homogeneously expressed in developing nervous system. Expression levels in mammary glands are barely detectable in virgin mice, levels increase during pregnancy, reaching a maximum during late pregnancy, then decrease during lactation becoming very low post-lactation. {ECO:0000269|PubMed:17285328}.
Protein families：POU transcription factor family, Class-2 subfamily