LAT1_MOUSE Q9Z127
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UniProt:Q9Z127
Recommended name：Large neutral amino acids transporter small subunit 1
EC number：
Alternative names：(4F2 light chain) (4F2 LC) (4F2LC) (L-type amino acid transporter 1) (LAT1) (Solute carrier family 7 member 5)
Cleaved into：
GeneID：20539
Gene names (primary )：Slc7a5
Gene names (synonym )：Lat1
Gene names (ORF )：
Length：512
Mass：55872
Sequence：MAVAGAKRRAVATPAAAAAEEERQAREKMLEARRGDGADPEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLSLVVWAVCGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPVFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFIQMGKDMGQGDASNLQQKLSFEGTNLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTNQMLTSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSVLSMIHPQLLTPVPSLVFTCIMTLMYAFSRDIFSIINFFSFFNWLCVALAIIGMMWLRFKKPELERPIKVNLALPVFFILACLFLIAVSFWKTPMECGIGFAIILSGLPVYFFGVWWKNKPKWILQAIFSVTVLCQKLMQVVPQET
Tissue specificity：Detected in brain, spleen, liver and testis (at protein level) (PubMed:9915839). Predominantly expressed in the microvessels in the brain parenchyma of the central nervous system. Also detected in the subfornical organ, the subcommissural organ, ventromedial nucleus of the hypothalamus, subgranular zone of the dentate gyrus in hippocampus, ependymal layer of the lateral ventricles, and the olfactory bulb. Very strong expression also seen in testis, ovary, and placenta with weaker expression in spleen, skin, brain, thymus, stomach, lung, heart, kidney, small intestine, uterus and skeletal muscle. {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11011012, ECO:0000269|PubMed:11117468, ECO:0000269|PubMed:9915839}.
Induction：Expression induced by concanavalin-A stimulation. {ECO:0000269|PubMed:9915839}.
Developmental stage：Strong expression in the liver of 14 dpc embryo. In embryo of 18 dpc expressed strongly in brain, moderate expression in spleen and brain and weak expression in liver. {ECO:0000269|PubMed:9915839}.
Protein families：Amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2.A.3.8) family