CASPE_HUMAN P31944
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UniProt:P31944
Recommended name：Caspase-14
EC number：EC:3.4.22.-
Alternative names：(CASP-14)
Cleaved into：Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form
GeneID：23581
Gene names (primary )：CASP14
Gene names (synonym )：
Gene names (ORF )：
Length：242
Mass：27680
Sequence：MSNPRSLEEEKYDMSGARLALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRLYLQ
Tissue specificity：Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels (PubMed:11175259). The p17/10 mature form is expressed in epidermis stratum corneum, the p20/p8 intermediate form in epidermis upper granular cells of the stratum granulosum (PubMed:22825846). {ECO:0000269|PubMed:11175259, ECO:0000269|PubMed:15556625, ECO:0000269|PubMed:22825846}.
Induction：In undifferentiated keratinocytes under postconfluency growth conditions (in vitro) (PubMed:11175259). By high glucose in retinal pigment epithelia cells (PubMed:25121097). {ECO:0000269|PubMed:11175259, ECO:0000269|PubMed:25121097}.
Developmental stage：
Protein families：Peptidase C14A family