CDK6_HUMAN Q00534
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UniProt:Q00534
Recommended name：Cyclin-dependent kinase 6
EC number：EC:2.7.11.22
Alternative names：(Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)
Cleaved into：
GeneID：1021
Gene names (primary )：CDK6
Gene names (synonym )：CDKN6
Gene names (ORF )：
Length：326
Mass：36938
Sequence：MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
Tissue specificity：Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells. {ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:8114739}.
Induction：Down-regulated in response to enterovirus 71 (EV71) infection. Induced by NANOG during S-phase entry. {ECO:0000269|PubMed:16548883, ECO:0000269|PubMed:19139263}.
Developmental stage：
Protein families：Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily