TREM2_HUMAN   Q9NZC2


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UniProt:Q9NZC2

Recommended name:Triggering receptor expressed on myeloid cells 2

EC number:

Alternative names:(TREM-2) (Triggering receptor expressed on monocytes 2)

Cleaved into:

GeneID:54209

Gene names  (primary ):TREM2

Gene names  (synonym ):

Gene names  (ORF ):

Length:230

Mass:25447

Sequence:MEPLRLLILLFVTELSGAHNTTVFQGVAGQSLQVSCPYDSMKHWGRRKAWCRQLGEKGPCQRVVSTHNLWLLSFLRRWNGSTAITDDTLGGTLTITLRNLQPHDAGLYQCQSLHGSEADTLRKVLVEVLADPLDHRDAGDLWFPGESESFEDAHVEHSISRSLLEGEIPFPPTSILLLLACIFLIKILAASALWAAAWHGQKPGTHPPSELDCGHDPGYQLQTLPGLRDT

Tissue specificity:Expressed in the brain, specifically in microglia and in the fusiform gyrus (at protein level) (PubMed:28802038, PubMed:28855300, PubMed:27477018, PubMed:29752066). Expressed on macrophages and dendritic cells but not on granulocytes or monocytes (PubMed:10799849, PubMed:28855301). In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord (PubMed:12080485). {ECO:0000269|PubMed:10799849, ECO:0000269|PubMed:12080485, ECO:0000269|PubMed:27477018, ECO:0000269|PubMed:28802038, ECO:0000269|PubMed:28855300, ECO:0000269|PubMed:28855301, ECO:0000269|PubMed:29752066}.

Induction:

Developmental stage:

Protein families:


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