S22A4_HUMAN Q9H015
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UniProt:Q9H015
Recommended name：Solute carrier family 22 member 4
EC number：
Alternative names：(Ergothioneine transporter) (ET transporter) (Organic cation/carnitine transporter 1)
Cleaved into：
GeneID：6583
Gene names (primary )：SLC22A4
Gene names (synonym )：ETT OCTN1 UT2H
Gene names (ORF )：
Length：551
Mass：62155
Sequence：MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMETEENPKVLITAF
Tissue specificity：Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells. {ECO:0000269|PubMed:14608356, ECO:0000269|PubMed:15107849, ECO:0000269|PubMed:9426230}.
Induction：Overexpressed upon TNF treatment. {ECO:0000269|PubMed:14608356}.
Developmental stage：
Protein families：Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family