S22A1_MOUSE O08966
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UniProt:O08966
Recommended name：Solute carrier family 22 member 1
EC number：
Alternative names：(Organic cation transporter 1) (mOCT1)
Cleaved into：
GeneID：20517
Gene names (primary )：Slc22a1
Gene names (synonym )：Lx1 Oct1
Gene names (ORF )：
Length：556
Mass：61521
Sequence：MPTVDDVLEHVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPDHHCRSPGVAELSQRCGWSPAEELNYTVPGLGSAGEASFLSQCMKYEVDWNQSTLDCVDPLSSLAANRSHLPLSPCEHGWVYDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSLSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQVAFTVGLVGLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKNRKVPPADLKMMCLEEDASERRSPSFADLFRTPSLRKHTLILMYLWFSCAVLYQGLIMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFIPHELHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLSAGAVTLLLPETKGVALPETIEEAENLGRRKSKAKENTIYLQVQTGKSPHT
Tissue specificity：Highly expressed in liver, kidney and intestine. Weakly expressed in adrenals and in lacting mammary glands. {ECO:0000269|PubMed:16381671, ECO:0000269|PubMed:8854860}.
Induction：Increased by PPARA and PPARG treatment in both liver and H35 cells. {ECO:0000269|PubMed:15458920}.
Developmental stage：Weakly expressed 2 days before birth, but gradually increased during the first 3 weeks of age, reaching a plateau around day 22 in both kidney and liver. At 45 days of age, renal and hepatic levels is 4 to 6 times higher than the level immediately after birth. {ECO:0000269|PubMed:16381671}.
Protein families：Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family