ASTL_MOUSE Q6HA09
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UniProt:Q6HA09
Recommended name：Astacin-like metalloendopeptidase
EC number：EC 3.4.-.-
Alternative names：(Oocyte astacin) (Ovastacin) (Sperm acrosomal SLLP1-binding protein)
Cleaved into：
GeneID：215095
Gene names (primary )：Astl
Gene names (synonym )：Sas1b
Gene names (ORF )：
Length：435
Mass：47455
Sequence：MGIMGSLWPWILTMLSLLGLSMGAPSASRCSGVCSTSVPEGFTPEGSPVFQDKDIPAINQGLISEETPESSFLVEGDIIRPSPFRLLSVTNNKWPKGVGGFVEIPFLLSRKYDELSRRVIMDAFAEFERFTCIRFVAYHGQRDFVSILPMAGCFSGVGRSGGMQVVSLAPTCLRKGRGIVLHELMHVLGFWHEHSRADRDRYIQVNWNEILPGFEINFIKSRSTNMLVPYDYSSVMHYGRFAFSWRGQPTIIPLWTSSVHIGQRWNLSTSDITRVCRLYNCSRSVPDSHGRGFEAQSDGSSLTPASISRLQRLLEALSEESGSSAPSGSRTGGQSIAGLGNSQQGWEHPPQSTFSVGALARPPQMLADASKSGPGAGADSLSLEQFQLAQAPTVPLALFPEARDKPAPIQDAFERLAPLPGGCAPGSHIREVPRD
Tissue specificity：Ovary-specific. Expressed in secondary, antral and Graafian follicle oocytes. Expressed in the egg cells. Not detected in two-cell embryos. Not detected in naked oocytes, oocytes in primordial or unilaminar primary follicles, or in any other ovarian cells at pre-pubertal, pubertal or adult stages (at protein level). Ovary-specific. {ECO:0000269|PubMed:22206759, ECO:0000269|PubMed:22472438}.
Induction：Up-regulated by superovulation. {ECO:0000269|PubMed:15087446}.
Developmental stage：Expressed in embryonic stem cells. Highly expressed in unfertilized oocytes. Upon fertilization, expression drops to undetectable levels, although at 1.5 dpc a significant amount of ovastacin RNA could still be detected. Not detected from 1.5 dpc to implantation of the embryo. {ECO:0000269|PubMed:15087446, ECO:0000269|PubMed:22275110}.
Protein families：