EDAR_MOUSE Q9R187
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UniProt:Q9R187
Recommended name：Tumor necrosis factor receptor superfamily member EDAR
EC number：
Alternative names：(Anhidrotic ectodysplasin receptor 1) (Downless) (Ectodermal dysplasia receptor) (Ectodysplasin-A receptor)
Cleaved into：
GeneID：13608
Gene names (primary )：Edar
Gene names (synonym )：Dl
Gene names (ORF )：
Length：448
Mass：48434
Sequence：MAHVGDCKWMSWLPVLVVSLMCSAKAEDSNCGENEYHNQTTGLCQQCPPCRPGEEPYMSCGYGTKDDDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGVSAHSSSTSGGSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMFYIMKTKPSAPACCSSPPGKSAEAPANTHEEKKEAPDSVVTFPENGEFQKLTATPTKTPKSENDASSENEQLLSRSVDSDEEPAPDKQGSPELCLLSLVHLAREKSVTSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASPPPAAS
Tissue specificity：
Induction：By activin A in 12 dpc dental epithelium. {ECO:0000269|PubMed:11203701}.
Developmental stage：Transcripts are not detectable in the branchial arch epithelium before morphological tooth formation (10 dpc), but are highly expressed during the initiation of tooth development (11 dpc). Starting 12 dpc, expression is high and limited to the budding cells, and remains high in the fully developed enamel knot at 14 dpc, whereas all other dental cells were completely negative. During 15 dpc the enamel knot disappears largely through apoptosis, and no transcripts were detected in the tooth germs of newborns. In skin, uniformly distributed in the basal cells of the epidermis before follicle initiation. Expression becomes focally elevated before placodes become distinguishable. By 17 dpc transcripts are almost exclusively confined to maturing follicles and the recently initiated placodes.
Protein families：