TRPA1_MOUSE Q8BLA8
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UniProt:Q8BLA8
Recommended name：Transient receptor potential cation channel subfamily A member 1
EC number：
Alternative names：(Ankyrin-like with transmembrane domains protein 1) (Wasabi receptor)
Cleaved into：
GeneID：277328
Gene names (primary )：Trpa1
Gene names (synonym )：Anktm1
Gene names (ORF )：
Length：1125
Mass：128467
Sequence：MKRGLRRILLPEERKEVQGVVYRGVGEDMDCSKESFKVDIEGDMCRLEDFIKNRRKLSKYEDENLCPLHHAAAEGQVELMELIINGSSCEVLNIMDGYGNTPLHCAAEKNQVESVKFLLSQGANPNLRNRNMMSPLHIAVHGMYNEVIKVLTEHKATNINLEGENGNTALMSTCAKDNSEALQILLEKGAKLCKSNKWGDYPVHQAAFSGAKKCMELILAYGEKNGYSRETHINFVNHKKASPLHLAVQSGDLDMIKMCLDNGAHIDMMENAKCMALHFAATQGATDIVKLMISSYTGSSDIVNAVDGNQETLLHRASLFDHHDLAEYLISVGADINSTDSEGRSPLILATASASWNIVNLLLCKGAKVDIKDHLGRNFLHLTVQQPYGLRNLRPEFMQMQHIKELVMDEDNDGCTPLHYACRQGVPVSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEEGNTALHFAAREGHAKAVAMLLSYNADILLNKKQASFLHIALHNKRKEVVLTTIRNKRWDECLQVFTHNSPSNRCPIMEMVEYLPECMKVLLDFCMIPSTEDKSCQDYHIEYNFKYLQCPLSMTKKVAPTQDVVYEPLTILNVMVQHNRIELLNHPVCREYLLMKWCAYGFRAHMMNLGSYCLGLIPMTLLVVKIQPGMAFNSTGIINGTSSTHEERIDTLNSFPIKICMILVFLSSIFGYCKEVIQIFQQKRNYFLDYNNALEWVIYTTSIIFVLPLFLNIPAYMQWQCGAIAIFFYWMNFLLYLQRFENCGIFIVMLEVIFKTLLRSTGVFIFLLLAFGLSFYVLLNFQDAFSTPLLSLIQTFSMMLGDINYRDAFLEPLFRNELAYPVLTFGQLIAFTMFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTNLEKKLPLWYLRKVDQRSTIVYPNRPRHGRMLRFFHYFLNMQETRQEVPNIDTCLEMEILKQKYRLKDLTSLLEKQHELIKLIIQKMEIISETEDEDNHCSFQDRFKKERLEQMHSKWNFVLNAVKTKTHCSISHPDF
Tissue specificity：Expressed in inner ear (at protein level). Specifically expressed in a subset of nociceptive neurons. Expressed in the same neurons that TRPV1. In contrast, it is not expressed in neurons expressing TRPM8. Expressed in the superior cervical ganglion of vagus nerve. Expressed in the inferior ganglion (nodose ganglion) of vagus nerve (PubMed:21873995). Expressed in dorsal root ganglia neurons (PubMed:21873995). {ECO:0000269|PubMed:12654248, ECO:0000269|PubMed:15194861, ECO:0000269|PubMed:15483558, ECO:0000269|PubMed:15843607, ECO:0000269|PubMed:21873995}.
Induction：
Developmental stage：During utricle development, it is first expressed at 15 dpc and 16 dpc and peaks at 17 dpc. It drops at 18 dpc but increases again at 19 dpc, possibly corresponding to a second wave of hair cells that are generated at 15 dpc. {ECO:0000269|PubMed:15483558}.
Protein families：Transient receptor (TC 1.A.4) family