MMP12_HUMAN P39900
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UniProt:P39900
Recommended name：Macrophage metalloelastase
EC number：EC:3.4.24.65
Alternative names：(MME) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12)
Cleaved into：
GeneID：4321
Gene names (primary )：MMP12
Gene names (synonym )：HME
Gene names (ORF )：
Length：470
Mass：54002
Sequence：MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
Tissue specificity：Found in alveolar macrophages but not in peripheral blood monocytes.
Induction：By exposure to bacterial lipopolysaccharides (LPS). Inhibited by dexamethasone.
Developmental stage：
Protein families：Peptidase M10A family