HDAC9_MOUSE Q99N13
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UniProt:Q99N13
Recommended name：Histone deacetylase 9
EC number：EC 3.5.1.98
Alternative names：(HD9) (Histone deacetylase 7B) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR)
Cleaved into：
GeneID：79221
Gene names (primary )：Hdac9
Gene names (synonym )：Hdac7b Hdrp Mitr
Gene names (ORF )：
Length：588
Mass：65687
Sequence：MHSMISSVDVKSEVPMGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVGRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDSKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNLVTSFKKRVFEVAESSVSSSSPGSGPSSPNNGPAGNVTENEASALPPTPHPEQLVPQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSPLNASNSLKDKQKCETQMLRQGVPLPSQYGSSIAASSSHVHVAMEGKPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQSMEDRAASKDNSARSDSSACVEDTLGQVGAVKVKEEPVDSDEDAQIQEMECGEQAAFMQQVIGKDLAPGFVIKVII
Tissue specificity：Expressed at high levels in heart, brain and spleen. Expressed in skeletal muscle. {ECO:0000269|PubMed:11390982, ECO:0000269|PubMed:15711539}.
Induction：By MEF2 during muscle differentiation. Down-regulated by muscle denervation. Down-regulated by trichostatin A or sodium butyrate, and during neuronal apoptosis (at protein level). {ECO:0000269|PubMed:17101791}.
Developmental stage：At 10.5 dpc, expressed in heart, skeletal muscle and neural lineages. At 11.5d pc, expressed in heart, dorsal root ganglia and neural tube. At 12.5 dpc, expressed in heart, skeletal muscle, dorsal root ganglia, neural tube and retina. Strongly up-regulated in muscle between 14 and 19 dpc as a result of motor innervation. {ECO:0000269|PubMed:11390982, ECO:0000269|PubMed:15711539, ECO:0000269|PubMed:17101791}.
Protein families：Histone deacetylase family, HD type 2 subfamily