MELK_MOUSE Q61846
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UniProt:Q61846
Recommended name：Maternal embryonic leucine zipper kinase
EC number：EC 2.7.11.1
Alternative names：(Protein kinase PK38) (mPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)
Cleaved into：
GeneID：17279
Gene names (primary )：Melk
Gene names (synonym )：Kiaa0175 Pk38
Gene names (ORF )：
Length：643
Mass：72729
Sequence：MKDYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPVEWQSKTPLTHLDEDCVTELSVHHRSSRQTMEDLISSWQYDHLTATYLLLLAKKARGKPARLQLLSFSCGTASTTPKSKNLSLEDMSTSDDNCVAGLIDYELCEDKLLAPKTPQVTKHLAESNHAASKSPAPGVRRAVANKLMDKENVCTPKSSVKNEEQFVFSEPKIPVSKNQYKREIPASPTRFPTPAKARAQCLREAPVRTPGNSAGADTLTTGVISPERRCRSMDVDLNQAHMEDTPKKKGTNVFGSLERGLDKVLTALTRNKKKGSARDGPRKRKLHYNVTTTRLVNPDQLLSEIMAILPKKNVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQRPDVVGIRRQRLKGDAWVYKRLVEDILSGCKM
Tissue specificity：Expressed in testis, ovary, thymus, spleen and T-cell. Expressed by neural progenitors: highly enriched in cultures containing multipotent progenitors. {ECO:0000269|PubMed:16061694, ECO:0000269|PubMed:9136115, ECO:0000269|PubMed:9305775}.
Induction：
Developmental stage：Expressed in the 2-cell-stage embryo, followed by a strong expression at 8-cell-stage. {ECO:0000269|PubMed:9136115}.
Protein families：Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily