CML1_MOUSE P97468
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UniProt:P97468
Recommended name：Chemokine-like receptor 1
EC number：
Alternative names：(G-protein coupled receptor DEZ)
Cleaved into：
GeneID：14747
Gene names (primary )：Cmklr1
Gene names (synonym )：Dez Gpcr27
Gene names (ORF )：
Length：371
Mass：41815
Sequence：MEYDAYNDSGIYDDEYSDGFGYFVDLEEASPWEAKVAPVFLVVIYSLVCFLGLLGNGLVIVIATFKMKKTVNTVWFVNLAVADFLFNIFLPMHITYAAMDYHWVFGKAMCKISNFLLSHNMYTSVFLLTVISFDRCISVLLPVWSQNHRSIRLAYMTCSAVWVLAFFLSSPSLVFRDTANIHGKITCFNNFSLAAPESSPHPAHSQVVSTGYSRHVAVTVTRFLCGFLIPVFIITACYLTIVFKLQRNRLAKNKKPFKIIITIIITFFLCWCPYHTLYLLELHHTAVPSSVFSLGLPLATAVAIANSCMNPILYVFMGHDFRKFKVALFSRLANALSEDTGPSSYPSHRSFTKMSSLNEKASVNEKETSTL
Tissue specificity：Expressed in the differentiated adipocytes (at protein level). Ubiquitous. Highly expressed in adipose tissue and immature plasmacytoid dendritic cells (DCs) and at lower levels in myeloid DCs, macrophages, and NK cells. Expressed on macrophages isolated from different tissues, including peritoneal cavities, pleural cavities and spleen. {ECO:0000269|PubMed:16863918, ECO:0000269|PubMed:17635925, ECO:0000269|PubMed:17767914, ECO:0000269|PubMed:18242188, ECO:0000269|PubMed:19841182}.
Induction：Down-regulated by bacterial lipopolysaccharide (LPS), IFN-alpha and TNF on macrophages. {ECO:0000269|PubMed:16863918}.
Developmental stage：Expressed during bone development and in adult parathyroid glands. Expressed at 11 dpc in the caudal part of the tongue and the umbilical cord and the expression in the tongue was maintained throughout adulthood. Expression increases in bone and cartilaginous forming zones of embryo up to stage 14.5 dpc and at 16.5 dpc expression is seen in the lung. {ECO:0000269|PubMed:9144535}.
Protein families：G-protein coupled receptor 1 family