CR3L3_MOUSE Q91XE9
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UniProt:Q91XE9
Recommended name：Cyclic AMP-responsive element-binding protein 3-like protein 3
EC number：
Alternative names：(cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H)
Cleaved into：Processed cyclic AMP-responsive element-binding protein 3-like protein 3
GeneID：208677
Gene names (primary )：Creb3l3
Gene names (synonym )：Crebh
Gene names (ORF )：
Length：479
Mass：52145
Sequence：MDGDIAAGKMASPVCAMAPLDSMEVLDLLFDRQDGILRNVELAEGWILAREEQKVLLNSDSDEFLNCILGPGDSDPSSPLWSPADSDSGISEDLPSDPQDTPPRSGTEPANTVARCHTREQGKGPCPSYLPSTPCPEPPRTQVQESSVAIDLDMWSTDTLYPEEPAGSPSRFNLTVKELLLSGGSGDLQQHSLAASQLLGPGSGHCQELVLTEDEKKLLAKEGVTLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLENRMSACTAQNQELQRKVLHLEKQNLSLLEQLKHLQALVVQSTSKPAHAGTCIAVLLLSFALIILPSISPFNSNKVDSPGDFVPVRVFSRTLHNHAASRVAPDVTPGSEVPGPWPDVGTPHKGPSSGGLSADWGNFLEIPMLDNLTEELDNSTLVLANSTEDLGRATLLDWVASEPLLSPGRVGLEIPGEMWLSWVPRWLRVRLVQDALGVL
Tissue specificity：Exclusively expressed in adult liver (at protein level). {ECO:0000269|PubMed:15800215, ECO:0000269|PubMed:30389664}.
Induction：By IL6. Proinflammatory cytokines and lipopolysaccharide activate the UPR and induce cleavage of CREBH in the liver (PubMed:16469704). Down-regulated in the liver during fasting-refeeding. This down-regulation may occur at the postranscriptional level and may be mediated by SYNV1/HRD1, which induces CREB3L3 ubiquitination and proteasomal degradation (PubMed:30389664). {ECO:0000269|PubMed:16469704, ECO:0000269|PubMed:30389664}.
Developmental stage：
Protein families：BZIP family, ATF subfamily