RSPO1_MOUSE Q9Z132
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UniProt:Q9Z132
Recommended name：R-spondin-1
EC number：
Alternative names：(Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3) (Roof plate-specific spondin-1)
Cleaved into：
GeneID：192199
Gene names (primary )：Rspo1
Gene names (synonym )：
Gene names (ORF )：
Length：265
Mass：29332
Sequence：MRLGLCVVALVLSWTHIAVGSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCQEALYLHKGRCYPACPEGSTAANSTMECGSPAQCEMSEWSPWGPCSKKRKLCGFRKGSEERTRRVLHAPGGDHTTCSDTKETRKCTVRRTPCPEGQKRRKGGQGRRENANRHPARKNSKEPRSNSRRHKGQQQPQPGTTGPLTSVGPTWAQ
Tissue specificity：Expressed in the dorsal part of the neural tube on 10 and 12 dpc, especially in the boundary region between roof plate and neuroepithelium. This expression is enhanced in the rostral part. Also expressed in other tissues such as truncal region neighboring forelimbs and mesenchymal tissues around the nasal cavity. {ECO:0000269|PubMed:14732490}.
Induction：
Developmental stage：Transiently expressed in the central nervous system (CNS) during development. Predominantly expressed in the tailbud of embryos. Also detected in the primitive streak, dorsal neural tube, forebrain and migrating neural crests of embryos. Detected from day 9.5, in various neural and mesodermal derivatives, mainly along dorsal neural tube and diencephalon. Strongly expressed in limb buds, particularly in the morphogenetically active region such as the apical ectodermal ridge (AER). The developing skin showed expression in patches of the developing dermis at 12.5 dpc and at lower levels at 14.5 dpc. By 18.5 dpc expression is restricted to the dermal papilla of the developing hair, which persisted into adulthood. In the developing kidney, strong expression at 11.5 dpc in the uninduced metanephric mesenchyme is observed. By 14.5 dpc this expression is restricted to the condensing mesenchyme surrounding the ureter and the developing nephrons. Specific expression in the urogenital ridge as early as 10.5 dpc in the coelomic epithelium. Sex-specific differences of expression began to appear starting at 12.5 dpc, with an increase in the somatic cells of the XX gonad. {ECO:0000269|PubMed:14732490, ECO:0000269|PubMed:15469841, ECO:0000269|PubMed:16543246, ECO:0000269|PubMed:17041600}.
Protein families：R-spondin family