I17RC_MOUSE Q8K4C2
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UniProt:Q8K4C2
Recommended name:Interleukin-17 receptor C
EC number:
Alternative names:(IL-17 receptor C) (IL-17RC) (Interleukin-17 receptor-like protein) (IL-17RL) (ZcytoR14)
Cleaved into:
GeneID:171095
Gene names (primary ):Il17rc
Gene names (synonym ):
Gene names (ORF ):
Length:698
Mass:77148
Sequence:MPVSWFLLSLALGRNPVVVSLERLMEPQDTARCSLGLSCHLWDGDVLCLPGSLQSAPGPVLVPTRLQTELVLRCPQKTDCALCVRVVVHLAVHGHWAEPEEAGKSDSELQESRNASLQAQVVLSFQAYPIARCALLEVQVPADLVQPGQSVGSAVFDCFEASLGAEVQIWSYTKPRYQKELNLTQQLPDCRGLEVRDSIQSCWVLPWLNVSTDGDNVLLTLDVSEEQDFSFLLYLRPVPDALKSLWYKNLTGPQNITLNHTDLVPCLCIQVWSLEPDSERVEFCPFREDPGAHRNLWHIARLRVLSPGVWQLDAPCCLPGKVTLCWQAPDQSPCQPLVPPVPQKNATVNEPQDFQLVAGHPNLCVQVSTWEKVQLQACLWADSLGPFKDDMLLVEMKTGLNNTSVCALEPSGCTPLPSMASTRAARLGEELLQDFRSHQCMQLWNDDNMGSLWACPMDKYIHRRWVLVWLACLLLAAALFFFLLLKKDRRKAARGSRTALLLHSADGAGYERLVGALASALSQMPLRVAVDLWSRRELSAHGALAWFHHQRRRILQEGGVVILLFSPAAVAQCQQWLQLQTVEPGPHDALAAWLSCVLPDFLQGRATGRYVGVYFDGLLHPDSVPSPFRVAPLFSLPSQLPAFLDALQGGCSTSAGRPADRVERVTQALRSALDSCTSSSEAPGCCEEWDLGPCTTLE
Tissue specificity:Highly expressed in colonic epithelial cells (PubMed:19144317). Expressed in lung epithelial cells (PubMed:28813677). Expressed in macrophages (PubMed:19144317). Highly expressed in B-1a B cells and at a lower extent in B-1b and B-2 B cells (at protein level) (PubMed:26735852). {ECO:0000269|PubMed:19144317, ECO:0000269|PubMed:26735852, ECO:0000269|PubMed:28813677}.
Induction:Induced in lung epithelial cells upon bacterial and fungal infection. Up-regulated in lung epithelial cells by IL17F; this might account for a persistent activation via a positive feedback loop. {ECO:0000269|PubMed:28813677}.
Developmental stage:
Protein families: