KCP_MOUSE Q3U492
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UniProt:Q3U492
Recommended name：Kielin/chordin-like protein
EC number：
Alternative names：(Cysteine-rich BMP regulator 2) (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin/chordin-like protein 1) (KCP-1)
Cleaved into：
GeneID：333088
Gene names (primary )：Kcp
Gene names (synonym )：Crim2 Kcp1
Gene names (ORF )：
Length：1550
Mass：166628
Sequence：MAGARAALLPLLLHLGSLALAARGGEVSREQPRLADAISQQQAPSHSLVPGETHQQQWCPLEERLERLEAEVTDLRKQNRELQARVVQLESCECWGPGHTCPEGARWEPDACTACVCRDGTAHCGPQPNLPHCRGCSHNGQSYGHGETFSPDACTTCRCLAGTVQCQGPSCSELNCLESFIPPGECCPICRPGCEYEGQLHQEGSSFLSSSNPCLQCSCLRSLVRCVPVKCQPSPCLNPVPRLGHCCPVCQASGCTEGNSHRDHGQEWTTPGDPCRICQCLEGHIQCRQRECASLCPYPARPLPGTCCPVCDGCFLNGREHSSGEPVGSQDPCSSCRCTNGSVQCEPLPCPPAPCRYPGRIPGQCCPVCDGCKYQGHEYRSQETFTLQENGRCLRCVCQAGEVSCEEQDCPVTPCVRSASGPQLCSACVLNGEEFAEGIQWEPDDQPCTSCSCQDGVPVCRAVLCSPVPCQHPTQPPGACCPSCDSCTYHSLVYANGQNFTDVDSPCQTCYCEDGTVRCSLINCPFTTCAKPQNGPGQCCPKCPDCILEAQVFVDGERFPHPRDPCQECWCQEGQAHCQLRACPSAPCVHPLPGTCCKNDCTGCAFGGKEYPNGADFPHPTDPCRLCRCLSGNVQCLARRCPPLSCPQPVLTPGDCCPQCPDAPADCPQSGNMVPVRHQEHFFQPGDPCSRCLCLDGSVSCQRLTCPPAPCAHPRRDACCPSCDGCLYQGKEFASGERFPSPNVACHVCLCWEGSVKCEPRTCAPAQCPFPTREDCCPACDSCDYLGVSYLSSQEFPDPREACNLCTCLGGFVTCTRRPCEPPACSHPLIVPEHCCPTCQGCLYHGITAALGETLPDPLDPTCSLCTCEEGSMRCQKKPCPPAPCAHPSPGPCFCPVCRSCLSQGREHQDGEEFEGPEGSCERCRCLAGQVSCTRLQCPSLPCLHQVTEPGTCCPRCTGCLARGEEHPEGSSWVPADSPCSSCMCHKGIITCAQVQCVSACIWPQEGPSDCCPQCSGCEHGGRKYEPGESFQPGADPCEVCICKQKREGPPSLHCSRRQCPSLVGCPPSQLLPPGPQHCCPTCAQALSNCTEDLVGSELVPPDPCYTCQCQDLTWLCTHRACPELSCPLWERHTTPGSCCPVCKDPTQSCMHQGRWVASGEQWAVDACTSCSCVAGTVHCQTQRCRKLACSRDEVPALSPGSCCLRCLPRPASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKDCHGEDFSVHVTNDDRGRRGVAWTQEVAVLLGTVAVRLLQGRTVMVDQHTVTLPFLREPLLYIELRGHTVILHAQPGLQVLWDGQSQVEVRVPSSYRGQTCGLCGNFNGFAQDDLQGPDGRLLPTEASFGNSWKVPKGLGPGRPCSAGREVDPCRAAGYRARREANARCGILKTSPFSHCHAVVPPEPFFAACVYDLCACGPGSSSDTCLCDALEAYASHCRQAGVTPVWRGPTLCVVGCPVDRGFVFDECGPPCPRTCFNRHIPLGELAAHCVRPCVPGCQCPAGLVEHEGHCISPEVCPPVLLTGD
Tissue specificity：Weakly expressed in embryonic kidney and brain. Not expressed in adult tissues and several cell lines. {ECO:0000269|PubMed:15793581}.
Induction：By renal stresses. {ECO:0000269|PubMed:15793581}.
Developmental stage：Prominently expressed in two areas, the limb buds and the developing kidney, with diffuse staining in the central nervous system. At 9.5 dpc the limb bud mesenchyme is positive. Expression in the kidney region could be detected as early as 9 dpc in the intermediate mesoderm. By 10 dpc, the mesonephric tubules and nephric ducts are clearly positive. At later stages, high levels are localized to the developing tubules. At 18.5 dpc, it is localized to more mature renal tubules located in the developing cortex with little expression detected in the nephrogenic zone. {ECO:0000269|PubMed:15793581}.
Protein families：