I23O1_MOUSE P28776
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UniProt:P28776
Recommended name：Indoleamine 2,3-dioxygenase 1
EC number：EC 1.13.11.52
Alternative names：(IDO-1) (Indoleamine-pyrrole 2,3-dioxygenase)
Cleaved into：
GeneID：15930
Gene names (primary )：Ido1
Gene names (synonym )：Ido Indo
Gene names (ORF )：
Length：407
Mass：45641
Sequence：MALSKISPTEGSRRILEDHHIDEDVGFALPHPLVELPDAYSPWVLVARNLPVLIENGQLREEVEKLPTLSTDGLRGHRLQRLAHLALGYITMAYVWNRGDDDVRKVLPRNIAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLLVEIAASPAIKAIPTVSSAVERQDLKALEKALHDIATSLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKCSSKLPEGLLYEGVWDTPKMFSGGSAGQSSIFQSLDVLLGIKHEAGKESPAEFLQEMREYMPPAHRNFLFFLESAPPVREFVISRHNEDLTKAYNECVNGLVSVRKFHLAIVDTYIMKPSKKKPTDGDKSEEPSNVESRGTGGTNPMTFLRSVKDTTEKALLSWP
Tissue specificity：Highly expressed in epididymis, duodemum, jejunum, ileum, colon and spleen (PubMed:19741271). Highly expressed in epididymis, prostate, duodemum, jejunum, ileum, colon and spleen, not detected in the liver (at protein level) (PubMed:19741271). Expressed in tumors only upon exposure to IFN gamma (PubMed:25691885). Constitutively expressed in placenta in trophoblast cells (PubMed:15063630). Expression is restricted to perinuclear regions of primary trophoblast giant cells (TGCs) of fetal origin at mid-gestation (E10.5). After placentation (E14), no IDO expression was detected at the maternal-fetal interface (PubMed:15063630). {ECO:0000269|PubMed:15063630, ECO:0000269|PubMed:19741271, ECO:0000303|PubMed:25691885}.
Induction：By IFNG/IFN-gamma in most cells. {ECO:0000250|UniProtKB:P14902}.
Developmental stage：
Protein families：Indoleamine 2,3-dioxygenase family