BUD23_HUMAN O43709
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UniProt:O43709
Recommended name：Probable 18S rRNA (guanine-N(7))-methyltransferase
EC number：EC:2.1.1.-
Alternative names：(Bud site selection protein 23 homolog) (Metastasis-related methyltransferase 1) (Williams-Beuren syndrome chromosomal region 22 protein) (rRNA methyltransferase and ribosome maturation factor)
Cleaved into：
GeneID：114049
Gene names (primary )：BUD23
Gene names (synonym )：MERM1 WBSCR22
Gene names (ORF )：HUSSY-03 PP3381
Length：281
Mass：31880
Sequence：MASRGRRPEHGGPPELFYDETEARKYVRNSRMIDIQTRMAGRALELLYLPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMGQGIPFKPGTFDGCISISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATKAGFSGGMVVDYPNSAKAKKFYLCLFSGPSTFIPEGLSENQDEVEPRESVFTNERFPLRMSRRGMVRKSRAWVLEKKERHRRQGREVRPDTQYTGRKRKPRF
Tissue specificity：Widely expressed, with high levels in heart, skeletal muscle and kidney. Detected at high levels in bronchial brushings and in normal lung (at protein level). In fetal lung tissue, expressed in the developing bronchial lumen lining cells (at protein level). Tends to be down-regulated in lungs affected by inflammatory diseases or neoplasia (at protein level). Expressed in immune cells, including B and T lymphocytes and macrophages. {ECO:0000269|PubMed:11978965, ECO:0000269|PubMed:12073013, ECO:0000269|PubMed:24488492}.
Induction：Up-regulated in CD8+ T lymphocytes by treatment with anti-CD3 and in B lymphocytes by treatment with CD40 ligand and anti-B cell receptor antibody. In macrophages, no induction following LPS treatment. Down-regulated by a combined treatment with TNF and IFNG (at protein level). {ECO:0000269|PubMed:24488492}.
Developmental stage：
Protein families：Class I-like SAM-binding methyltransferase superfamily, BUD23/WBSCR22 family