PDK1_HUMAN Q15118
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UniProt:Q15118
Recommended name：[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
EC number：EC:2.7.11.2
Alternative names：(Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)
Cleaved into：
GeneID：5163
Gene names (primary )：PDK1
Gene names (synonym )：PDHK1
Gene names (ORF )：
Length：436
Mass：49244
Sequence：MRLARLLRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
Tissue specificity：Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas. {ECO:0000269|PubMed:7499431}.
Induction：Up-regulated via the HIF1A signaling pathway in response to hypoxia. {ECO:0000269|PubMed:21763680}.
Developmental stage：
Protein families：PDK/BCKDK protein kinase family