WLS_MOUSE Q6DID7
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UniProt:Q6DID7
Recommended name：Protein wntless homolog
EC number：
Alternative names：(Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI)
Cleaved into：
GeneID：68151
Gene names (primary )：Wls
Gene names (synonym )：Gpr177
Gene names (ORF )：
Length：541
Mass：62188
Sequence：MAGAIIENMSTKKLCIVGGILLVFQIVAFLVGGLIAPAPTTAVPYTAIKCVDVRKNHHKTRWLAPWGPNKCDKIRDIEEAIPREIEANDIVFSVHIPLPSMEMSPWFQFMLFILQLDIAFKLNNQIRENAEISMDVSLGYRDDMFSEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYNCDVLPFMEIGSVAHKYYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDVGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVSEGHWKWGGVTVQVSSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHSGEELQLTTTITHVDGPTEIYKLTRKEAQE
Tissue specificity：Expressed in the brain, skeletal muscle, heart muscle, lung, gut, liver, and kidney (at protein level) (PubMed:20652957). In the brain, expressed in the cortex, striatum, hippocampus and to a lesser extent in the cerebellum (at protein level) (PubMed:20652957). Expressed in kidney, lung, skin, intestine, brain, spinal cord, skeleton, eyes, excretion glands, tooth and palatal shelves (PubMed:19841259). In the cerebellum, expressed in Purkinje cells (PubMed:19841259). {ECO:0000269|PubMed:19841259, ECO:0000269|PubMed:20652957}.
Induction：Up-regulated by WNT1. Transcriptionally activated by beta-catenin and by LEF/TCF-dependent transcription. {ECO:0000269|PubMed:19841259}.
Developmental stage：Detected at 6.25 dpc in the proximal epiblast at the junction between the embryonic and extraembryonic tissue. Later expression is more restricted to the primitive streak and mesoderm extending to the distal tip of the embryo. Strong expression is found in both posterior visceral endoderm and epiblast at the prestreak, but switched to the mesoderm at late-streak. {ECO:0000269|PubMed:19841259}.
Protein families：Wntless family