Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection. IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, IRF-9/ISGF3γ, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E).
Product List
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
| IRF1 | AMRe02171 | IRF1 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC-F,IHC-P,ICC/IF,IP |
| IRF1 | APRab00047 | IRF1 Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC-P,ICC/IF,FC,IP |
| IRF5 | AMRe03898 | IRF5 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC-P,ICC/IF,FC,IP |
| IRF7 | AMRe02793 | IRF7 Rabbit Monoclonal Antibody | Human,Rat | WB,IHC-F,IHC-P,ICC/IF,IP |
| IRF8 | AMRe02172 | IRF8 Rabbit Monoclonal Antibody | Human | WB,IHC-P,IP |
| IRF-4 | APRab12745 | IRF-4 Rabbit Polyclonal Antibody | Human,Mouse | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA |
| IRF-3 | APRab12743 | IRF-3 Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA |
| IRF-3 | APRab12742 | IRF-3 Rabbit Polyclonal Antibody | Human,Rat,Mouse,Pig | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA |
| IRF-3 (phospho Ser396) | APRab04870 | IRF-3 (phospho Ser396) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC-P |
| IRF-2 | APRab12739 | IRF-2 Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA |
| IRF-7 (phospho-Ser477) | APRab04872 | IRF-7 (phospho-Ser477) Rabbit Polyclonal Antibody | Human,Rat,Mouse | WB,IHC-P |
| IRF-9 (3N8) | AMRe12750 | IRF-9 (3N8) Rabbit Monoclonal Antibody | Human | WB,ICC/IF,FC |
| IRF2 (19Z15) | AMRe12738 | IRF2 (19Z15) Rabbit Monoclonal Antibody | Human,Mouse | WB,IHC-P,ICC/IF,IF-P |
| IRF7 (1D12) | AMRe12748 | IRF7 (1D12) Rabbit Monoclonal Antibody | Human | WB,IP |
| IRF5 (Phospho-Ser437) | APRab05783 | IRF5 (Phospho-Ser437) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB |
| IRF-3 (phospho Ser386) | APRab04869 | IRF-3 (phospho Ser386) Rabbit Polyclonal Antibody | Human,Rat,Mouse | WB,IHC-P |
| IRF-1 | APRab12737 | IRF-1 Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,ELISA,IHC-P |
| Phospho-IRF3 (Ser386) (9P16) | AMRe05928 | Phospho-IRF3 (Ser386) (9P16) Rabbit Monoclonal Antibody | Human | WB |
| Phospho-IRF3 (S386) (7S3) | AMRe05927 | Phospho-IRF3 (S386) (7S3) Rabbit Monoclonal Antibody | Human | WB,ICC/IF |
| IRF-3 (phospho Ser385) | APRab04868 | IRF-3 (phospho Ser385) Rabbit Polyclonal Antibody | Human,Rat,Mouse | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA |
| IRF3 | AMRe21447 | IRF3 Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA |
| IRF3 | AMM82960 | IRF3 Mouse Monoclonal Antibody | Human, Mouse, Rat | IHC,ICC,FC,ELISA |
| IRF3 | AMM82968 | IRF3 Mouse Monoclonal Antibody | Human, Mouse, Rat | WB,IHC,FC,ELISA |
| IRF5 | AMRe83838 | IRF5 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IP,IHC,ICC,FC,IF |
| IRF5 | AMRe83834 | IRF5 Rabbit Monoclonal Antibody | Human | WB,IHC,ICC,FC,IF |
| IRF6 | AMRe83836 | IRF6 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC,IF |
| IRF5 | AMM83120 | IRF5 Mouse Monoclonal Antibody | Human | WB,IP |
| IRF9 | AMM83337 | IRF9 Mouse Monoclonal Antibody | Human | IP,IHC |
| IRF8 | AMRe87356 | IRF8 Rabbit Monoclonal Antibody | Human | WB, IHC-P, IP |
| IRF3 | AMRe87473 | IRF3 Rabbit Monoclonal Antibody | Human,Mouse | WB, IHC-P, ICC/IF, FC |
| IRF8 | AMRe85716 | IRF8 Rabbit Monoclonal Antibody | Human | WB,IP,IHC |
Related Products
Super-sensitive ECL chemiluminescent reagent
References
- IRF family of transcription factors as regulators of host defense. Taniguchi T, et al. Annu Rev Immunol. 2001. [PMID: 11244049]
- IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Honda K, et al. Nat Rev Immunol. 2006. [PMID: 16932750]
- Evolution of the IRF Family in Salmonids. Clark TC, et al. Genes (Basel). 2021. [PMID: 33567584]
- The IRF family transcription factors at the interface of innate and adaptive immune responses. Ikushima H, et al. Cold Spring Harb Symp Quant Biol. 2013. [PMID: 24092468]
- IRF family of transcription factors as regulators of host defense. Taniguchi T, et al. Annu Rev Immunol. 2001. [PMID: 11244049]
- Ubiquitination modification: critical regulation of IRF family stability and activity. Liu BQ, et al. Sci China Life Sci. 2021. [PMID: 33141302]
