ATX1_MOUSE P54254
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UniProt:P54254
Recommended name：Ataxin-1
EC number：
Alternative names：(Spinocerebellar ataxia type 1 protein homolog)
Cleaved into：
GeneID：20238
Gene names (primary )：Atxn1
Gene names (synonym )：Sca1
Gene names (ORF )：
Length：791
Mass：83793
Sequence：MKSNQERSNECLPPKKREIPATSRPSEEKATALPSDNHCVEGVAWLPSTPGIRGHGGGRHGSAGTSGEHGLQGMGLHKALSAGLDYSPPSAPRSVPTANTLPTVYPPPQSGTPVSPVQYAHLSHTFQFIGSSQYSGPYAGFIPSQLISPSGNPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQAPGHKVEPPPQQHLSRAAGLVNPGSPPPPTQQNQYIHISSSPQSSGRATSPPPIPVHLHPHQTMIPHTLTLGPSSQVVVQYSDAGGHFVPRESTKKAESSRLQQAMQAKEVLNGEMEKSRRYGASSSVELSLGKASSKSVPHPYESRHVVVHPSPADYSSRDTSGVRGSVMVLPNSSTPSADLEAQQTTHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGGLPQHLVIPGNQPLLIPVGSPDMDTPGAASAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPTTASPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEESHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKQAKTDSLAGSRHRYAEQENGINQGSAQVLSENGELKFPEKIGLPAAPFLSKIEPSKPTATRKRRWSAPETRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
Tissue specificity：Expressed in the cortex and hypothalamus (at protein level). Widely expressed. In brain, the pattern of distribution is limited to neuron populations. {ECO:0000269|PubMed:28288114, ECO:0000269|PubMed:8789437}.
Induction：Atxn1 protein levels are directly regulated by Pum1 protein: Pum1 acts by binding to the 3'-UTR of Atxn1 mRNA, affecting Atxn1 mRNA stability and leading to reduced Atxn1 protein levels. {ECO:0000269|PubMed:25768905}.
Developmental stage：Transient expression burst in Purkinje cells as the cerebellar cortex becomes functional (postnatal day 14), and in mesenchymal cells of the developing intervertebral disks of the spinal column. {ECO:0000269|PubMed:8789437}.
Protein families：ATXN1 family