ASIC3_RAT O35240
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UniProt:O35240
Recommended name：Acid-sensing ion channel 3 Curated
EC number：
Alternative names：Amiloride-sensitive cation channel 3 Dorsal root ASIC 1 Publication (DRASIC 1 Publication)
Cleaved into：
GeneID：286920
Gene names (primary )：Asic3
Gene names (synonym )：Accn3 Imported, Drasic 1 Publication
Gene names (ORF )：
Length：533
Mass：59,227
Sequence：MKPRSGLEEAQRRQASDIRVFASSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQVAERVRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYLRALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQPCGPENFTVIFTRMGQCYTFNSGAHGAELLTTPKGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHSQDEPPAIDQLGFGAAPGHQTFVSCQQQQLSFLPPPWGDCNTASLDPDDFDPEPSDPLGSPRPRPSPPYSLIGCRLACESRYVARKCGCRMMHMPGNSPVCSPQQYKDCASPALDAMLRKDTCVCPNPCATTRYAKELSMVRIPSRASARYLARKYNRSESYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFIGASLLTILEILDYLCEVFQDRVLGYFWNRRSAQKRSGNTLLQEELNGHRTHVPHLSLGPRPPTTPCAVTKTLSASHRTCYLVTRL
Tissue specificity：Expressed in sciatic nerve and dorsal root ganglion (at protein level) (PubMed:11842212). Expressed in sensory neurons of dorsal root ganglion. Expressed in Golgi interneurons in the granular layer. Also found in superior cervical ganglia, spinal cord and brain stem 4 s
Induction：Expression is first detected at 15.5 dpc. Strongly expressed perinatally. 1 Publication
Developmental stage：Transcriptionally regulated by the proinflammatory mediators nerve growth factor (NGF), serotonin, interleukin-1 and bradykinin (PubMed:12486159, PubMed:14522957). Up-regulation upon tissue inflammation is abolished by anti-inflammatory drugs (PubMed:11588175). 3 s
Protein families：amiloride-sensitive sodium channel (TC 1.A.6) family