STRA8_MOUSE P70278
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UniProt:P70278
Recommended name：Stimulated by retinoic acid gene 8 protein
EC number：
Alternative names：
Cleaved into：
GeneID：20899
Gene names (primary )：Stra8
Gene names (synonym )：
Gene names (ORF )：
Length：393
Mass：44555
Sequence：MATPGEGNQPSDDGAPQPLAQLQKLEPRVVRRRLSQARHRATLVGLFNNLRKAVYSQSDITASKWQVLNRTKIHIQEQEESLDKLLKLKASFNLQDGNPNSLEEVKEEYARMYSENDSVFLNSFLQDSPPEWFPSEAVGPDAEEEGEEEGEEEGEEGEEEEEGDEEGEEEEENGEEREVEEYQEEEEEEEEEEKKVDLSHSSSTLLPDLMEFERYLNFYKQTMDLLTMNSIISAHEVTLPIVSAAISHLWQTLSEEKKARLLQVWEQQHSAFADLTEACLELAGVEGSMKDSGVDSQGASCSLESTPEEILFEDAFDVASFLDKSEAQHMSNISAMFATCNSENPEEKFQLYIQIIEFFKSLGCVNTPLNQEPEPPDDDDAMLLKCLETFDDL
Tissue specificity：Expressed exclusively in premeiotic germ cells in both sexes. In females, is expressed in the embryonic ovary. In males, is expressed in pubertal and adult testes, in premeiotic spermatogenic cells. Expressed by some type A and B spermatogonia, preleptotene spermatocytes, and early leptotene spermatocytes (at protein level). Expression begins in late undifferentiated spermatogonia and persists during differentiating spermatogonia (at protein level). {ECO:0000269|PubMed:16461896, ECO:0000269|PubMed:18799790, ECO:0000269|PubMed:25902548, ECO:0000269|PubMed:32032549, ECO:0000269|PubMed:8896602}.
Induction：Up-regulated by retinoic acid in embryonic ovaries and adult testes, and by all-trans and 9-cis retinoic acid in P19 embryonic carcinoma (EC) cells. Transcription is repressed by DMRT1 in undifferentiated spermatogonia. {ECO:0000269|PubMed:16461896, ECO:0000269|PubMed:18322276, ECO:0000269|PubMed:20951351, ECO:0000269|PubMed:8896602}.
Developmental stage：Up-regulated in embryonic germ cells of the female gonads in an anterior-to-posterior wave from 12.5 dpc to 16.5 dpc. In male gonads, expression is first detected after birth. {ECO:0000269|PubMed:14550793, ECO:0000269|PubMed:16461896, ECO:0000269|PubMed:32032549}.
Protein families：