Hedgehog proteins are secreted ligands that enable long-range communication between cells of developing and adult tissues. The core molecular components of the pathway are evolutionarily conserved and were first identified in the fruit fly Drosophila melanogaster nearly a century ago, first through mutant analysis and later by systematic genetic screens. These studies elucidated the signaling mechanism by which cells sense the concentration of hedgehog in their vicinity, which in certain contexts can be integrated with the duration of hedgehog exposure. These signal transduction events converge onto downstream gene-regulatory networks to regulate processes including cell proliferation, stem cell maintenance, survival, and fate specification. Many of the genes that encode hedgehog pathway components have subsequently been associated with a range of inherited human developmental disorders and other pathologies. The phenotype of congenital hedgehog deficiency is similar to that seen with genetic mutations causing defective cholesterol metabolism. At the molecular level, three observations link hedgehog signal transduction with cholesterol biosynthesis: hedgehog ligands are covalently modified by cholesterol; the hedgehog receptor patched (PTCH) contains a sterol-sensing domain (SSD), which is found in proteins involved in cholesterol synthesis and transport; and cholesterol, its precursors, and derivatives activate or inhibit smoothened (SMO), the membrane transducer of hedgehog signaling.
Product List
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
Tyrosine Hydroxylase (14U19) | Tyrosine Hydroxylase (14U19) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC-P,ICC/IF |
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