The history of “immature” neurons was not a straight one (blue strip). The first step occurred at the beginning of the nineties, in the context of studies on adhesion molecules in the nervous system. At that time, several laboratories were showing the existence of molecules affecting cell-to-cell contacts in the brain by modulating adhesion. This research field was (and still is) considered of paramount importance in the perspective of modulating neuronal, neuro-glial, and synaptic plasticity.
The results obtained in the cerebral cortex would suggest a rather sharp definition of “immature” neurons as non-newly generated, prenatally generated cells. Nevertheless, the situation appears more complex and poorly defined since other populations of DCX+/PSA-NCAM+ cells do occur in various non-neurogenic regions of the mammalian CNS, possibly falling into the definition of “immature” neurons.
Product List
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
Doublecortin | AMRe01412 | Doublecortin Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB |
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Super-sensitive ECL chemiluminescent reagent
References
- Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule. Hoffman S, et al. Proc Natl Acad Sci U S A. 1983. [PMID: 6577452]
- The neural cell adhesion molecule (NCAM) as a regulator of cell-cell interactions. Rutishauser U, et al. Science. 1988. [PMID: 3281256]
- NCAM polysialic acid can regulate both cell-cell and cell-substrate interactions. Acheson A, et al. J Cell Biol. 1991. [PMID: 2050739]
- Polysialylation and disease. Sato C, et al. Mol Aspects Med. 2021. [PMID: 32863045]
- Polysialic acid and activity-dependent synapse remodeling. Bonfanti L, et al. Cell Adh Migr. 2009. Epub 2009 Jan 23. [PMID: 19372729]
- Cell adhesion molecules regulating astrocyte-neuron interactions. Tan CX, et al. Curr Opin Neurobiol. 2021. [PMID: 33957433]
- The PSA-NCAM-Positive "Immature" Neurons: An Old Discovery Providing New Vistas on Brain Structural Plasticity. Bonfanti L, et al. Cells. 2021. [PMID: 34685522]
