Summary
Performance
Immunogen
Application
Background
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010],catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.,pathway:Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.,PTM:Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Interacts with ERAS.,tissue specificity:Expressed predominantly in leukocytes.,
Research Area
Inositol phosphate metabolism;ErbB_HER;Chemokine;Phosphatidylinositol signaling system;mTOR;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;VEGF;Focal adhesion;Toll_Like;Jak_STAT;Natural killer cell mediated cytotoxicity;T_Cell_Receptor;B_Cell_Antigen;Fc epsilon RI;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin;Regulates Actin and Cytoskeleton;Insulin_Receptor;Progesterone-mediated oocyte maturation;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Chronic myeloid leukemia;Acute myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;
