XRCC4 (7C10) Mouse Monoclonal Antibody

XRCC4 (7C10) Mouse Monoclonal Antibody

Size1:50μL Price1:$150
Size2:100μL Price2:$280
Size3:200μL Price3:$520
Application:WB,IHC-F,IHC-P,ICC/IF,IP
Reactivity:Human,Mouse,Rat
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:XRCC4 SKU: AMM03579 Category: Mouse Monoclonal Antibody Tags: , , , , , , , , ,

Datasheet

Summary

Production Name

XRCC4 (7C10) Mouse Monoclonal Antibody

Description

Mouse Monoclonal Antibody

Host

Mouse

Application

WB,IHC-F,IHC-P,ICC/IF,IP

Reactivity

Human,Mouse,Rat

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG1

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification

Affinity Purification

 

Immunogen

Gene Name

XRCC4

Alternative Names

X ray repair cross complementing protein 4; DNA repair protein XRCC4; DNA double strand break repair

Gene ID

7518

SwissProt ID

Q13426

 

Application

Dilution Ratio

WB: 1:500-1:1000 IHC: 1:50-1:100 IF: 1:50-1:200 IP: 1:20

Molecular Weight

Calculated MW: 38 kDa; Observed MW: 38-45 kDa

 

Background

Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

 

Research Area

Epigenetics and Nuclear Signaling

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