Phospho-Rb (Ser807) Rabbit Monoclonal Antibody

Phospho-Rb (Ser807) Rabbit Monoclonal Antibody

Size1:50μL Price1:$188
Size2:100μL Price2:$338
Size3:200μL Price3:$520
Application:WB,IHC-F,IHC-P,ICC/IF
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:RB1 SKU: AMRe03902 Category: Rabbit Monoclonal Antibody Tags: , , , , , , , ,

Datasheet

Summary

Production Name

Phospho-Rb (Ser807) Rabbit Monoclonal Antibody

Description

Rabbit Monoclonal antibody

Host

Rabbit

Application

WB,IHC-F,IHC-P,ICC/IF

Reactivity

Human, Mouse, Rat

 

Performance

Conjugation

Unconjugated

Modification

Phosphorylated

Isotype

IgG

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Purification

Affinity Purification

 

Immunogen

Gene Name

RB1

Alternative Names

RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

Gene ID

5925

SwissProt ID

P06400

 

Application

Dilution Ratio

WB: 1:500-1:1000 IHC: 1:50-1:100 IF: 1:50-1:200

Molecular Weight

Calculated MW:106 kDa;Observed MW: 110 kDa

 

Background

Cell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression. Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation. Specificity of different CDK/cyclin complexes has been observed in vitro and cyclin D1 is required for Ser780 phosphorylation in vivo.

 

Research Area

Cell Biology

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